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CASE REPORT article
Front. Cardiovasc. Med.
Sec. Heart Valve Disease
Volume 12 - 2025 | doi: 10.3389/fcvm.2025.1487543
Metagenomic Next-Generation Sequencing Identifies Native Valve Aspergillus fumigatus Endocarditis with Cerebral Involvement: A Case Report
Provisionally accepted- 1 Qingyuan People's Hospital, Qingyuan, China
- 2 Zhejiang University School of Medicine, Hangzhou, China
Aspergillus endocarditis is a rare but highly fatal condition, particularly in immunocompromised patients. This case report describes a 74-year-old male with native valve Aspergillus fumigatus endocarditis and intracranial infection. Diagnosis was complicated by atypical presentation and negative blood cultures, but metagenomic nextgeneration sequencing (mNGS) enabled rapid identification of the pathogen. This case is notable for being the first to document Aspergillus fumigatus endocarditis with cerebral involvement confirmed by mNGS, highlighting the importance of early diagnosis and advanced diagnostic tools in improving outcomes.
Keywords: MNGs, case, Aspergillus endocarditis, Intracranial infection, diagnosis
Received: 02 Sep 2024; Accepted: 19 Feb 2025.
Copyright: © 2025 Wu, Xu, Ruan, Tian and Xuan. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Bao-ping Tian, Zhejiang University School of Medicine, Hangzhou, China
Nan-xia Xuan, Zhejiang University School of Medicine, Hangzhou, China
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