95% of researchers rate our articles as excellent or good
Learn more about the work of our research integrity team to safeguard the quality of each article we publish.
Find out more
ORIGINAL RESEARCH article
Front. Cardiovasc. Med.
Sec. Lipids in Cardiovascular Disease
Volume 12 - 2025 | doi: 10.3389/fcvm.2025.1484693
A clinical study into the impact of brief aerobic exercise on the cardiopulmonary function of patients diagnosed with hyperlipidemia
Provisionally accepted- Beijing Shijitan Hospital, Capital Medical University, Beijing, China
The aim of this study was to examine the effectiveness of brief aerobic exercise on patients diagnosed with hyperlipidemia. Methods: Seventy patients diagnosed with hyperlipidemia were enrolled from community health centers between May 2023 and October 2023. They were randomly assigned into two groups: test and control group, each consisting of 35 patients. The test group received personalized exercise recommendations along with routine medication, while the control group only received routine medication. The effectiveness of the intervention was assessed after 3 months. Various indicators including blood pressure, lipid levels, changes in cardiopulmonary function, 6-minute walk distance (6MWD) test results, the percentage of 6MWD relative to the predicted value (6MWD%Pred), copeptin (CPP), and fibroblast growth factor 21 (FGF21) were compared, before and after the intervention within each group and between the two groups. Results: After 3 months of personalized exercise, the test group showed significantly higher levels in three indicators compared to the control group. Specifically, the test group exhibited higher metabolic equivalent (MET) values ([ x ̅ ± SD, 4.6 ± 0.27 METs] vs [ x ̅ ± SD, 3.8 ± 1.06 METs]; P < 0.05), longer 6-minute walk distance (6MWD) ([( x ̅ ± SD, 488.08 ± 40.59 meters] vs [ x ̅ ± SD, 366.76 ± 160.49 meters]; P < 0.05), and a higher percentage of 6MWD relative to the predicted value (6MWD %Pred) ([ x ̅ ± SD, 92.8 ± 14.05] vs [ x ̅ ± SD, 71.3 ± 30.69]; P < 0.05). Additionally, within the test group, there was a significant increase in MET, 6MWD, and 6MWD%Pred compared to baseline (P < 0.05). Conclusion: Short-term aerobic exercise shows significant improvement in the cardiopulmonary function of patients with hyperlipidemia. However, it did not exhibit significant efficacy in managing hyperlipidemia.
Keywords: aerobic exercise, Cardiopulmonary function, copeptin (CPP), fibroblast, Hyperlipemia, growth factor 21 (FGF21)
Received: 22 Aug 2024; Accepted: 26 Mar 2025.
Copyright: © 2025 Zhang, Wang, Ge, Feng, Zhang, Liu and Zhang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Hua Zhang, Beijing Shijitan Hospital, Capital Medical University, Beijing, China
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.