Skip to main content

ORIGINAL RESEARCH article

Front. Cardiovasc. Med.
Sec. General Cardiovascular Medicine
Volume 12 - 2025 | doi: 10.3389/fcvm.2025.1476053
This article is part of the Research Topic Immune Cell Dynamics and Biomarkers in Cardiac Surgery-Induced Systemic Inflammatory Response View all articles

Predictive Value of Postoperative Prealbumin Levels for Detecting Early-Stage Complications Following Off-Pump Coronary Artery Bypass Grafting

Provisionally accepted
Yanting Jia Yanting Jia Jun Zhang Jun Zhang Lei Chen Lei Chen Yanhui Zhu Yanhui Zhu *
  • Department of Cardiovascular Surgery, Shandong Provincial Hospital affiliated to Shandong First Medical University, Jinan, China

The final, formatted version of the article will be published soon.

    Background: A pathological decrease in the serum prealbumin level is closely associated with the severity of various diseases and complications after surgery. Many patients suffer from a systemic inflammatory response and local myocardial ischemia after off-pump coronary artery bypass grafting, which is related to an adverse prognosis. This study aimed to explore the relationship between the serum prealbumin level and early complications following off-pump coronary artery bypass grafting, in addition to its predictive value.Methods: Data were retrospectively collected on patients undergoing off-pump coronary artery bypass grafting from January 2014 to July 2019. The serum prealbumin level was assessed within 6-12 hours after the operation. Patients were classified into two groups: the "normal" level group (≥17 mg/dL) and the "low" level group (<17 mg/dL). Univariate and multivariable analyses were performed to evaluate the predictive value of a low serum prealbumin level.Results: Of the 1002 patients, 553 (55.2%) had a low serum prealbumin level. The rate of pulmonary infection in the low group was significantly higher than in the normal group. Univariate analysis and multivariable analysis indicated that a low serum prealbumin level was associated with the increased incidence of postoperative pulmonary infection, pleural effusion, and new-onset atrial fibrillation.The serum prealbumin level following off-pump coronary artery bypass grafting serves as a crucial predictor for early major postoperative complications, such as pulmonary complications and new-onset atrial fibrillation. Early identification of high-risk patients by assessing serum 2 prealbumin levels, in addition to the timely adjustment of treatment and care strategies, can improve patient prognosis, shorten hospital stays, and reduce healthcare expenses.

    Keywords: Atrial Fibrillation, complications, Inflammatory Response, Off-pump coronary artery bypass grafting, Prealbumin

    Received: 05 Aug 2024; Accepted: 03 Feb 2025.

    Copyright: © 2025 Jia, Zhang, Chen and Zhu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Yanhui Zhu, Department of Cardiovascular Surgery, Shandong Provincial Hospital affiliated to Shandong First Medical University, Jinan, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.