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SYSTEMATIC REVIEW article
Front. Cardiovasc. Med.
Sec. Coronary Artery Disease
Volume 12 - 2025 | doi: 10.3389/fcvm.2025.1452006
Gender correlation between sleep duration and risk of coronary heart disease： a systematic review and meta-analysis
Provisionally accepted- 1 Dali University, Dali, China
- 2 affiliated hospital of Yunnan University, Kunming, China
Objective: The influence of extreme sleep duration on coronary heart disease (CHD) risk across genders remains a debated topic.Methods: This analysis gathers observational studies that explore association between varying sleep durations and CHD risks. Trend estimation employs generalized least squares, converting specific category risk estimates into relative risks (RR) per hour of sleep increase. A two-stage hierarchical regression model evaluates potential linear dose-response relationships. Data analysis utilizes random-effects restricted cubic spline models with four knots.Results: Involving 17 studies and 906,908 participants, this meta-analysis identifies a pronounced U-shaped nonlinear relationship between sleep duration and CHD risk applicable to both genders (P < 0.01). Notably, shorter sleep durations are linked to higher CHD risks in women, whereas longer durations are more consequential for men. The optimal sleep duration for minimizing CHD risk is between 7.0-8.0 hours daily for men and 7.5-8.5 hours for women.Conclusion: The influence of sleep duration on CHD risk differs significantly between genders.
Keywords: extreme sleep duration, coronary heart disease, gender, BMI, continent
Received: 20 Jun 2024; Accepted: 07 Mar 2025.
Copyright: © 2025 Li, Luo, Liang, Song and Fu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Jin-Xiao Fu, affiliated hospital of Yunnan University, Kunming, China
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