Myocardial intramural course may reduce left ventricular Ejection Fraction of patients suffering from coronary heart disease

Miaomiao Shi ¹ Jiaqi Zheng ² Xiaomeng Li ¹ Shanshan Li ¹ Jie Wang ¹ Kaicheng Liu ¹ Mei Jia ^1* Ming Su ^1*

• ¹ Peking University People's Hospital, Beijing, China
• ² Institute of Medical Technology, Health Science Centre, Peking University, Beijing, Beijing Municipality, China

Background Myocardial intramural course (MIC), a benign anatomical lesion, is an abnormal anatomical structure formed due to abnormal blood vessel routing. An increasing nuMICer of studies indicate that MIC is associated with coronary heart disease (CHD). However, it remains unclear whether MIC contributes to cardiac function impairment in patients with CHD. Thus, this study is to observe the association between MIC and cardiac function in patients with CHD.Methods All participants were recruited from the department of cardiology, Peking University People's Hospital from August 2022 to SepteMICer 2023. A total of 126 patients were diagnosed with MIC by coronary angiography (CAG) and/or coronary CT angiography (CTA). Among them, a total of 39 patients diagnosed with MIC and CHD were enrolled into the MIC-CHD group. Sixty cases of monthly stratified CHD patients were randomly selected, into the CHD group as controls.The left ventricular ejection fraction (LvEF) of patients in MIC-CHD group was lower than that in the CHD group (0.62 vs 0.67, p=0.0153). LvEF in patients of MIC-CHD was negatively correlated with the systolic stenosis degree of mural coronary artery (MCA) (r=-0.6474, p=0.0123) and MIC length (r=-0.5712, p=0.0414).The coMICination of MIC in patients with CHD may contribute to the reduction of LvEF, whereas MIC length and the systolic stenosis degree of MCA were negatively correlated with LvEF.