Clinical characteristics and outcomes of hospitalized patients with intracranial hemorrhage after percutaneous coronary intervention

Yujing Zhou Xin Su ^* Peng Liu Yi Tang Dong Cheng Haiyu Li Haiqiang Sang

• Department of Cardiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China

Objectives: Complications of intracranial hemorrhage (ICH) after percutaneous coronary intervention (PCI), although rare, have a poor prognosis with high mortality rates.This study aims to provide information on the clinical characteristics and outcomes of hospitalized patients with ICH after PCI. Materials and Methods: This retrospective study included 24 patients enrolled from February 2014 to September 2023, which occurred ICH during post-PCI hospitalization. We mainly analyzed general, procedural, ICH features and subsequent outcomes. In addition, the predictive ability of the CRUSADE, ARC-HBR, and ACUITY scores was assessed with the receiver operating characteristics area under the curve (AUC). Results: Among the 24 patients, the mean age was 62.21 ± 10.01 years, and 66.7% (n = 16) were men. The mortality of ICH patients after PCI was very high (n = 13, 54.2%). In addition, the most common initial manifestation of ICH patients was the disturbance of consciousness (n = 14, 58.3%). Over half of the cases (58.3%) occurred ICH within the first 12 hours following PCI. 13 patients (54.2%) had an ICH volume ≥ 30 cm 3 , and of these patients, a total of 11(84.6%) died. ICH volume ≥ 30 cm 3 (p = 0.038), and the use of mechanical ventilators (p = 0.011) were significantly higher in patients who died. The AUC of CRUSADE, ARC-HBR, and ACUITY scores were 0.500, 0.619, and 0.545, respectively.Conclusions: In our study, the mortality of ICH after PCI was high. The high volume of ICH indicates a high risk of death.