ORIGINAL RESEARCH article
Front. Cardiovasc. Med.
Sec. Atherosclerosis and Vascular Medicine
Volume 12 - 2025 | doi: 10.3389/fcvm.2025.1418587
Ultrasonic flow ratio measured immediately after successful rotational atherectomy with stent implantation predicts major adverse cardiovascular events
Provisionally accepted
Tao Zhao
Qing JinXi ZhangJiaji He
Guiping HeQiu ChenYikang SunPin GanJilei Zhang
Qiang Xue*Xuefeng Guang*- Yan'an Hospital Affiliated To Kunming Medical University, Kunming, China
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Introduction: The potential role of post-percutaneous coronary intervention (PCI) quantitative flow ratio (QFR) and ultrasonic flow ratio (UFR) in predicting adverse outcomes in patients with successful rotational atherectomy (RA) and stent placement remains to be defined. Methods: A total of 68 patients with highly calcific lesions, who underwent both QFR and UFR measurements after PCI with both RA and stenting, were enrolled. The major adverse coronary events (MACE) of 62 patients who completed 12-month follow-up were analyzed. The clinical characteristics of 9 patients with MACE and 53 non-MACE patients were compared. The predictors of MACE were analyzed using LASSO regression combined with Cox regression analyses.Results: Patients with MACE had more lipid-rich and mixed plaques, less stent expansion and symmetry index, and lower post-PCI QFR and UFR compared with non-MACE patients. Cox regression analyses found that patients with lower post-PCI QFR (P < 0.05) or lower post-PCI UFR (P < 0.01) had a significantly higher risk of MACE. Lasso regression was performed to select the most important predictors, and the subsequent Cox multivariate regression analyses showed that post-PCI UFR, mixed plaque, and stent expansion index were independent predictors of MACE (all P < 0.05). Multivariate linear regression analyses also found that changes in UFR (P < 0.05) and post-PCI UFR at minimal stent area (P < 0.01) were significantly associated with post-PCI UFR results.Conclusion: Lower value of post-PCI UFR is an independent predictor of 12-month MACE after PCI with RA and stent implantation in patients with highly calcified lesions.
Keywords: Rotational atherectomy, calcific coronary lesion, quantitative flow ratio, ultrasonic flow ratio, major adverse coronary events
Received: 17 May 2024; Accepted: 21 Apr 2025.
Copyright: © 2025 Zhao, Jin, Zhang, He, He, Chen, Sun, Gan, Zhang, Xue and Guang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Qiang Xue, Yan'an Hospital Affiliated To Kunming Medical University, Kunming, China
Xuefeng Guang, Yan'an Hospital Affiliated To Kunming Medical University, Kunming, China
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