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ORIGINAL RESEARCH article
Front. Cardiovasc. Med.
Sec. Cardiovascular Epidemiology and Prevention
Volume 12 - 2025 |
doi: 10.3389/fcvm.2025.1384090
This article is part of the Research Topic Mendelian Randomization and Cardiovascular Diseases View all 16 articles
Relationship Between Personality Traits and Spontaneous Coronary Artery Dissection Risk: Evidence from Mendelian Randomization
Provisionally accepted
Kun Zheng 
Mengdi Wu * Junhua Wang * Jinjin Sun * Yuqian Li * Peng Wang * Zhiyue Zhang *
Xiuming PAN Yifeng Yang * Tianqi Li * Yujie Guo *- Air Force Medical Center, Beijing, China
Background: Spontaneous coronary artery dissection (SCAD) significantly contributes to myocardial infarction among young individuals. Despite the elusive nature of its etiology, empirical evidence indicates a substantial correlation between sociopsychological factors and the disorder. This investigation endeavored to discern a genetic basis for personality traits influencing SCAD susceptibility. Methods: Bidirectional univariate and multivariate Mendelian randomization (MR) analyses were hereby conducted to investigate the putative causal nexus between personality dimensions and SCAD risk. Besides, data regarding SCAD and personality were extracted from expansive genome-wide association studies (GWAS), and rigorous statistical inferences were made using inverse variance weighting (IVW) and ancillary methodologies. Additionally, sensitivity evaluations were performed to bolster statistical assertions. Results: Univariate MR analyses indicated heightened neuroticism scores as harbingers of increased SCAD risk (Odds Ratio [OR] = 1.31, 95% Confidence Interval [CI]: 1.08-1.60, P = 0.007), while other personality characteristics revealed no causal interplay with SCAD. After excluding single nucleotide polymorphisms (SNPs) confounded by extrinsic variables, the association of neuroticism scores with SCAD susceptibility persisted. These findings were further substantiated by multivariate MR analyses. Conclusions: In summary, this study identified a significant association between genetically predicted neuroticism scores and an elevated risk of SCAD. However, additional investigation is still required to elucidate the biological underpinnings of this relationship, as well as the impact of gender , environmental influences, and other contributing factors.
Keywords: Myocardial Infarction, Spontaneous coronary artery dissection, personality trait, causality, Mendelian randomization
Received: 08 Feb 2024; Accepted: 31 Jan 2025.
Copyright: © 2025 Zheng, Wu, Wang, Sun, Li, Wang, Zhang, PAN, Yang, Li and Guo. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Mengdi Wu, Air Force Medical Center, Beijing, China
Junhua Wang, Air Force Medical Center, Beijing, China
Jinjin Sun, Air Force Medical Center, Beijing, China
Yuqian Li, Air Force Medical Center, Beijing, China
Peng Wang, Air Force Medical Center, Beijing, China
Zhiyue Zhang, Air Force Medical Center, Beijing, China
Yifeng Yang, Air Force Medical Center, Beijing, China
Tianqi Li, Air Force Medical Center, Beijing, China
Yujie Guo, Air Force Medical Center, Beijing, China
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