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ORIGINAL RESEARCH article

Front. Cardiovasc. Med.
Sec. Cardiovascular Epidemiology and Prevention
Volume 11 - 2024 | doi: 10.3389/fcvm.2024.1505905

Trends in Sepsis-Associated Cardiovascular Disease Mortality in the United States, 1999 to 2022

Provisionally accepted
Malik Salman Malik Salman 1*Jack Cicin Jack Cicin 1Ali Bin Abdul Jabbar Ali Bin Abdul Jabbar 1Ahmed El-shaer Ahmed El-shaer 1Abubakar Tauseef Abubakar Tauseef 1Noureen Asghar Noureen Asghar 1Mohsin Mirza Mohsin Mirza 1Ahmed Aboeata Ahmed Aboeata 2
  • 1 School of Medicine, Creighton University, Omaha, United States
  • 2 Department of Cardiology, Creighton University Medical Center, Omaha, United States

The final, formatted version of the article will be published soon.

    Purpose Cardiovascular disease (CVD) is the leading cause of death in the United States, and sepsis significantly contributes to hospitalization and mortality. This study aims to assess the trends of sepsis-associated CVD mortality rates and variations in mortality based on demographics and regions in the US. Methods The Centers for Disease Control and Prevention Wide-ranging Online Data for Epidemiologic Research (CDC WONDER) database was used to identify CVD and sepsis-related deaths from 1999 to 2022. Data on gender, race and ethnicity, age groups, region, and state classification were statistically analyzed to obtain crude and age-adjusted mortality rates (AAMR). The Joinpoint Regression Program was used to determine trends in mortality within the study period. Results During the study period, there were a total of 1,842,641 deaths with both CVD and sepsis listed as a cause of death. Sepsis-associated CVD mortality decreased between 1999 and 2013, from AAMR of 65.7 in 1999 to 58.8 in 2013 (APC -1.06*%, 95% CI: -2.12% to -0.26%), then rose to 74.3 in 2022 (APC 3.23*%, 95% CI: 2.18% to 5.40%). Throughout the study period, mortality rates were highest in men, NH Black adults, and elderly adults (65+ years old). The Northeast region, which had the highest mortality rate in the initial part of the study period, was the only region to see a decline in mortality, while the Northwest, Midwest, and Southern regions experienced significant increases in mortality rates. Conclusion Sepsis-associated CVD mortality has increased in the US over the past decade, and both this general trend and the demographic disparities have worsened since the onset of the COVID-19 pandemic.

    Keywords: Sepsis, cardiovascualr disease, COVID - 19, CDC WONDER Database, mortality trends

    Received: 03 Oct 2024; Accepted: 19 Nov 2024.

    Copyright: © 2024 Salman, Cicin, Abdul Jabbar, El-shaer, Tauseef, Asghar, Mirza and Aboeata. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Malik Salman, School of Medicine, Creighton University, Omaha, United States

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