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SYSTEMATIC REVIEW article

Front. Cardiovasc. Med.
Sec. General Cardiovascular Medicine
Volume 11 - 2024 | doi: 10.3389/fcvm.2024.1505298

SYSTEMATIC REVIEW: CHARACTERISTICS OF MYOCARDITIS FOLLOWED BY FIXED DRUG ERUPTION AND DRY EYE SYNDROME IN PATIENTS WHO HAVE BEEN VACCINATED WITH MONKEYPOX IN CHILDREN AND ADULTS

Provisionally accepted
R. Mohamad Javier R. Mohamad Javier 1*Stephanie Angela Prijanto Stephanie Angela Prijanto 2Vallexa Septina Yora Vallexa Septina Yora 3Desak Gede Yuliana Eka Pratiwi Desak Gede Yuliana Eka Pratiwi 4Errini Sabilla Lilhawa Ditsi Errini Sabilla Lilhawa Ditsi 3Bella Adelia Bella Adelia 3Verika Christabela Tansuri Verika Christabela Tansuri 5Hendry Wijaya Hendry Wijaya 6Georaldhy Yussufy Caecarma Georaldhy Yussufy Caecarma 7Intan Trikumala Damayanti Intan Trikumala Damayanti 3Anisa Ramadhanti Anisa Ramadhanti 3Atika Rahmaputri Atika Rahmaputri 3Chabib Fachry Albab Chabib Fachry Albab 7Afif Ferdian Afif Ferdian 8Fatih Farabi Fatih Farabi 9Fadila Risang Ayu Fadila Risang Ayu 10Ni Putu Ika Regina Maharani Ni Putu Ika Regina Maharani 11Andika Prasetyo Arifin Andika Prasetyo Arifin 12Eko Setyo Herwanto Eko Setyo Herwanto 3Saidah Rahmat A Saidah Rahmat A 3Safira Dita Arviana Safira Dita Arviana 13Syifa Nur Lathifah Syifa Nur Lathifah 14Nanda Rizki Yulinar Nanda Rizki Yulinar 15Laksmitha Saktiono Safitri Laksmitha Saktiono Safitri 3Basyar Adnani Basyar Adnani 13M. Rizki Fazrian Danu M. Rizki Fazrian Danu 16Natasya Naomi Natasya Naomi 17Dayu Dwi Deria Dayu Dwi Deria 18Aulia Syifa Aulia Syifa 18Panca Andana Panca Andana 18Adrian Prasetya Adrian Prasetya 18Fachira Rachel Agfata Fachira Rachel Agfata 18Magistra Cylvia Margaretha Magistra Cylvia Margaretha 18Subandono Bambang Indrasto Subandono Bambang Indrasto 19Sukirman Sukirman Sukirman Sukirman 18Rachmanto Rachmanto Rachmanto Rachmanto 20Hayatun Nufus Hayatun Nufus 21Pertiwi Febriana Chandrawati Pertiwi Febriana Chandrawati 22Aan Dwi Prasetyo Aan Dwi Prasetyo 23Lucky Sutanto Lucky Sutanto 24Moch Aleq Sander Moch Aleq Sander 25
  • 1 RSUPN Dr. Cipto Mangunkusumo, Jakarta, Indonesia
  • 2 Widya Mandala Catholic University Surabaya, Surabaya, East Java, Indonesia
  • 3 Faculty of Medicine, University of Muhammadiyah Malang, Malang, East Java, Indonesia
  • 4 Faculty of Medicine, University of Brawijaya, Malang, East Java, Indonesia
  • 5 School of Medicine, University of Pelita Harapan, Tangerang, Banten, Indonesia
  • 6 Atma Jaya Catholic University of Indonesia, Jakarta, Jakarta, Indonesia
  • 7 Faculty of Medicine, Airlangga University, Surabaya, East Java, Indonesia
  • 8 Permata Bunda Hospital, Malang, Indonesia
  • 9 Heartology Cardiovascular Hospital, Jakarta, Indonesia
  • 10 Faculty of Medicine, Diponegoro University, Semarang, Central Java, Indonesia
  • 11 Faculty of Medicine, Hang Tuah University, Jakarta, Jakarta, Indonesia
  • 12 Faculty of Medicine and Health Sciences, Krida Wacana Christian University, Jakarta, Jakarta, Indonesia
  • 13 Universitas Islam Negeri Maulana Malik Ibrahim, Malang, East Java, Indonesia
  • 14 Bayu Asih Purwakarta Hospital, Purwakartia, Indonesia
  • 15 Faculty of Medicine, University of Jember, Jember, East Java, Indonesia
  • 16 Universitas Malikussaleh, Reuleuet, Indonesia
  • 17 Islamic University of Indonesia, Yogyakarta, Special Region of Yogyakarta, Indonesia
  • 18 Gatot Soebroto Army Hospital, Jakarta, Jakarta, Indonesia
  • 19 Departement of Ophtalmologic, Gatot Soebroto Army Hospital, Jakarta, Indonesia
  • 20 Departement of Pediatric, Gatot Soebroto Army Hospital, Jakarta, Indonesia
  • 21 Departement of Internal Medicine, Persahabatan Hospital, Jakarta, Indonesia
  • 22 Departement of Pediatric, Muhammadiyah Malang University Hospital, Malang, Indonesia
  • 23 Departement of Neurology, Muhammadiyah Malang University Hospital, Malang, Indonesia
  • 24 Departement of Obstetrics and Gynecology Kartika Husada Tanjungpura, Tanjungpura, Indonesia
  • 25 Departement of Surgery Muhammadiyah Malang University Hospital, Malang, Indonesia

The final, formatted version of the article will be published soon.

    The Monkeypox Virus (MPOX) has caused a surge in viral infections, leading to the WHO recognizing it as a public health emergency of international concern. MPOX infection shares clinical similarities with smallpox but can cause complications like myocarditis, anorectal pain, ocular lesions, kidney damage, or soft tissue superinfection. The study aims to understand the characteristics of myocarditis, fixed drug eruption, and dry eye syndrome in Monkeypox patients.This review was conducted based on PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses), and the Cochrane Handbook for Systematic Reviews of Interventions. The data was obtained from Scopus and international journal databases by conducting combined keyword searches restricted to English-language publications.The study examined 25 cases of Monkeypox, primarily involving males aged 32.9 years and experiencing chest pain. The prognosis was generally good, with no reported death. Risk factors for infection include sexual activity, STD diagnosis, sexual encounters, and workplace exposure to orthopoxviruses. Most cases were male and involved chest pain. Myocarditis, an inflammation in the myocardium, can cause dilated cardiomyopathy, acute arrhythmia, and heart failure. The pathophysiology of myocarditis in Monkeypox patients is not yet determined due to rarity of cases.MPOX infection presents unique complications like myocarditis, necessitating research for vaccines, antiviral drugs, and infection prevention measures. Early screening for chest pain and investigating MPXV infection's pathogenesis and clinical features are crucial for differential diagnosis during outbreaks. This systematic review can determine MPOX infection outcomes and prepare appropriate treatment for patients with complications.

    Keywords: Monkeypox, Myocarditis, Dry eye syndrome, Drug eruption, Characteristics, And diagnosis

    Received: 02 Oct 2024; Accepted: 17 Dec 2024.

    Copyright: © 2024 Mohamad Javier, Prijanto, Yora, Yuliana Eka Pratiwi, Lilhawa Ditsi, Adelia, Tansuri, Wijaya, Caecarma, Damayanti, Ramadhanti, Rahmaputri, Albab, Ferdian, Farabi, Ayu, Ika Regina Maharani, Arifin, Herwanto, A, Arviana, Lathifah, Yulinar, Safitri, Adnani, Fazrian Danu, Naomi, Deria, Syifa, Andana, Prasetya, Agfata, Margaretha, Indrasto, Sukirman, Rachmanto, Nufus, Chandrawati, Prasetyo, Sutanto and Sander. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: R. Mohamad Javier, RSUPN Dr. Cipto Mangunkusumo, Jakarta, Indonesia

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