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REVIEW article

Front. Cardiovasc. Med.
Sec. Coronary Artery Disease
Volume 11 - 2024 | doi: 10.3389/fcvm.2024.1502909
This article is part of the Research Topic Animal Models of Vascular Interventions View all 3 articles

Preclinical Evaluation of Vascular Closure Devices

Provisionally accepted
Laura Perkins Laura Perkins *Merry Tu Merry Tu
  • Abbott Vascular, Santa Clara, CA, United States

The final, formatted version of the article will be published soon.

    Vascular closure devices (VCDs) are a diverse class of cardiovascular devices intended to achieve hemostasis following arteriotomy in the common femoral artery for diagnostic and therapeutic interventional procedures. While the preclinical evaluation of VCDs parallel that of many other cardiovascular devices, there are device-specific nuances and model-specific technical considerations in assessing in vivo performance and handling, determining safety, and satisfying regulatory requirements. Despite the multi-decade use and continued development of novel VCD technologies, there is a paucity of published literature on their preclinical evaluation. This review intends to help mitigate this gap through a discussion of conventional animal models, their attributes and limitations, and standards in the in vivo assessment of performance and safety of VCDs.

    Keywords: Percutaneous intervention, Vascular closure device, Hemostasis, Animal Models, Preclinical safety

    Received: 27 Sep 2024; Accepted: 28 Oct 2024.

    Copyright: © 2024 Perkins and Tu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Laura Perkins, Abbott Vascular, Santa Clara, CA, United States

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.