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ORIGINAL RESEARCH article

Front. Cardiovasc. Med.
Sec. Lipids in Cardiovascular Disease
Volume 11 - 2024 | doi: 10.3389/fcvm.2024.1500025
This article is part of the Research Topic HDL in Cardiovascular Disease: Unraveling the Protective Mechanisms and Clinical Implications View all articles

Association of cumulative non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio (NHHR) with the risk of cardiometabolic disease

Provisionally accepted
Luqing Liu Luqing Liu 1,2Shihe Liu Shihe Liu 1Yicheng Liao Yicheng Liao 1,2Xiaoxue Zhang Xiaoxue Zhang 1,2Meixiao Wang Meixiao Wang 1,2Liming Lin Liming Lin 1Chenrui Zhu Chenrui Zhu 1Shouling Wu Shouling Wu 1Yuntao Wu Yuntao Wu 1*
  • 1 Kailuan General Hospital Affiliated to North China University of Science and Technology, Kailuan General Hospital, Tangshan, Hebei Province, China
  • 2 Graduate School, North China University of Science and Technology, Tangshan, Hebei Province, China

The final, formatted version of the article will be published soon.

    Background: One measurement of non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio (NHHR) is considered to be associated with insulin resistance and cardiovascular disease (CVD) risk. This study aimed to exploring the association between cumulative non-high-density lipoprotein cholesterol/high-density lipoprotein cholesterol (Cum NHHR) exposure levels and the risk of cardiometabolic disease (CMD).: This prospective cohort study included 43,735 participants, who participated in three consecutive health examinations in 2006, 2008, 2010 and had no history of CMD or cancer. The participants were divided into quartiles bases on their cum NHHR. Multivariate Cox proportional hazards model was used to assess the association between cum NHHR and the risk of CMD.Additionally, the direct method of standardized ratios was employed to calculate the absolute risk of CMD attributable to cum NHHR.Results: Over a median follow-up period of 10.92 years (IQR: 10.22-11.26 years), 7,388 participants were newly diagnosed with CMD. In the multivariate-adjusted model, participants in quartiles Q2, Q3 and Q4 showed a progressively increased relative risk of CMD compared to those in Q1, The fully adjusted hazard ratios (95% confidence intervals) for the risk of CMD in the Q2, Q3, and Q4 groups were 1.11 (1.04-1.20), 1.23 (1.14-1.32), and 1.29 (1.20-1.38), respectively, compared with the Q1 group. This association remained significant even after further adjustment for single measurements of NHHR. Moreover, cum NHHR was positively correlated with the absolute risk of CMD, cardiovascular diseases (CVD), and type 2 diabetes (T2DM).Conclusions: Higher cum NHHR is significantly associated with an increased risk of CMD, independent of single-point NHHR level. Additionally, there are significant different strengths of correlations between cum NHHR and different diseases.

    Keywords: cardiometabolic disease, cumulative exposure, non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio, Epidemiology, Influencing factors

    Received: 22 Sep 2024; Accepted: 05 Nov 2024.

    Copyright: © 2024 Liu, Liu, Liao, Zhang, Wang, Lin, Zhu, Wu and Wu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Yuntao Wu, Kailuan General Hospital Affiliated to North China University of Science and Technology, Kailuan General Hospital, Tangshan, Hebei Province, China

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