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ORIGINAL RESEARCH article

Front. Cardiovasc. Med.
Sec. Cardiac Rhythmology
Volume 11 - 2024 | doi: 10.3389/fcvm.2024.1495129

Title：Cardiac deceleration capacity and acceleration capacity have diagnostic value in patients with vasovagal syncope regardless of age

Provisionally accepted
Jijing Wang Jijing Wang Jinyi Xu Jinyi Xu *Yanyan Qiu Yanyan Qiu *Ruike Yang Ruike Yang *Wentao Wang Wentao Wang *Chuanyu Gao Chuanyu Gao *
  • People's Hospital of Zhengzhou University, Zhengzhou, China

The final, formatted version of the article will be published soon.

    Background：Deceleration capacity (DC) and acceleration capacity (AC) are used to characterize autonomic regulation. The purpose of this study was to evaluate the autonomic nervous function in patients with vasovagal syncope (VVS) and to evaluate the diagnostic value of DC and AC for VVS. Methods: A total of 94 consecutive patients with VVS [51.0 (38.0~60.0) years; 48 males] and 76 healthy subjects [53.0 (44.3~62.8) years; 46 males] were recruited as controls. The study compared DC, AC, and heart rate variability (HRV) in 24-hour ECG, echocardiogram, and biochemical examinations between the two groups. Results: DC was significantly higher (9.3±2.1 versus 7.4±1.4 ms, p < .001) and AC was lower (-9.3±2.1 versus -7.3±1.3 ms, p < .001) in the syncope group compared to the control group. HRV indicators were higher in the syncope group. In multivariable analyses, DC (odds ratio=1.746 [95% CI, 1.389-2.195]; p < .001), AC (odds ratio=0.553 [95% CI, 0.435-0.702]; p < .001) were independently associated with syncope. Mean HR was associated with syncope only in patients ＜ 60 years of age. Receiver operating characteristics (ROC) curves showed areas under curve (AUC) of DC/AC for predicting syncope are 0.755/0.765 with sensitivity of 56.4%/60.6% and specificity of 93.4%/88.2%. Conclusion: Patients with VVS exhibit higher DC and lower AC. Both DC and AC are independently correlated with syncope. A DC value ＞9.0 ms and an AC value ＜-9.0 ms could potentially be valuable indicators for monitoring cardiac autonomic nervous dysfunction.

    Keywords: Deceleration capacity, Acceleration capacity, vasovagal syncope, Autonomic nervous function, Syncope

    Received: 24 Oct 2024; Accepted: 09 Dec 2024.

    Copyright: © 2024 Wang, Xu, Qiu, Yang, Wang and Gao. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Jinyi Xu, People's Hospital of Zhengzhou University, Zhengzhou, China
    Yanyan Qiu, People's Hospital of Zhengzhou University, Zhengzhou, China
    Ruike Yang, People's Hospital of Zhengzhou University, Zhengzhou, China
    Wentao Wang, People's Hospital of Zhengzhou University, Zhengzhou, China
    Chuanyu Gao, People's Hospital of Zhengzhou University, Zhengzhou, China

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