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ORIGINAL RESEARCH article

Front. Cardiovasc. Med.
Sec. Atherosclerosis and Vascular Medicine
Volume 11 - 2024 | doi: 10.3389/fcvm.2024.1491971
This article is part of the Research Topic New Trends in Vascular Biology 2024 View all 13 articles

Inhibition of angiogenesis and regenerative lung growth in Lep ob/ob mice through adiponectin-VEGF/VEGFR2 signaling

Provisionally accepted

The final, formatted version of the article will be published soon.

    Obesity is associated with impairment of wound healing and tissue regeneration. Angiogenesis, the formation of new blood capillaries, plays a key role in regenerative lung growth after unilateral pneumonectomy (PNX). We have reported that obesity inhibits angiogenesis. The effects of obesity on post-PNX lung vascular and alveolar regeneration remain unclear. Regenerative lung growth and expression of vascular endothelial growth factor (VEGF) and its receptor VEGFR2 induced after PNX are inhibited in Lep ob/ob obese mice. The levels of adiponectin that exhibits pro-angiogenic and vascular protective properties increase after unilateral PNX, while the effects are attenuated in Lep ob/ob obese mice. Post-PNX regenerative lung growth and increases in the levels of VEGF and VEGFR2 are inhibited in adiponectin knockout mice.Adiponectin stimulates angiogenic activities in human lung endothelial cells (ECs), which is inhibited by decreasing the levels of transcription factor Twist1.Adiponectin agonist, AdipoRon restores post-PNX lung growth and vascular and alveolar regeneration in Lep ob/ob obese mice. These findings suggest that obesity impairs lung vascular and alveolar regeneration and adiponectin is one of the key factors to improve lung regeneration in obese people.

    Keywords: Angiogenesis, Lung regeneration, Obesity, Adiponectin, VEGF

    Received: 05 Sep 2024; Accepted: 07 Oct 2024.

    Copyright: © 2024 Hunyenyiwa, Kyi, Scheer, Joshi, Gasparri, Mammoto and Mammoto. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Akiko Mammoto, Medical College of Wisconsin, Milwaukee, United States

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