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ORIGINAL RESEARCH article

Front. Cardiovasc. Med.
Sec. Cardio-Oncology
Volume 11 - 2024 | doi: 10.3389/fcvm.2024.1491912

Lung cancer and Risk of Cardiovascular Mortality

Provisionally accepted
Chengshi Wang Chengshi Wang 1Zhu Wang Zhu Wang 2Jing Yang Jing Yang 1*Songbo Zhang Songbo Zhang 1*Purong Zhang Purong Zhang 1*Ye Yang Ye Yang 1*
  • 1 Sichuan Cancer Hospital, Chengdu, China
  • 2 West China Hospital, Sichuan University, Chengdu, Sichuan Province, China

The final, formatted version of the article will be published soon.

    Purpose: To investigate the cardiovascular mortality risk among lung cancer patients compared to the general population. Methods: Using data from the National Cancer Institute's Surveillance, Epidemiology, and End Results program, we conducted a population-based cohort study including 278,418 lung cancer patients over 30 years old between January 1, 1990, and December 31, 2020 as well as the general population. Poisson regression was employed to calculate incidence rate ratios (IRRs) for cardiovascular mortality. Results: Patients exhibited a significantly higher incidence rate ratio (IRR) of cardiovascular mortality risk compared to the general population ([IRR 1.74, 95% confidence interval (CI) 1.71-1.77). ]. The risk was most pronounced in patients aged 30-79 years (IRR 2.61, 95% CI 2.55-2.66), peaking at ages 30-34 (IRR 48.93, 95% CI 21.98-108.92). Elevated cardiovascular mortality risks were observed across all subgroups, including diseases of the heart (IRR 1.79, 95% CI 1.75-1.82), cerebrovascular diseases (IRR 1.52, 95% CI 1.45-1.59), and other cardiovascular diseases (IRR 1.78, 95% CI 1.67-1.90). The first month post-diagnosis presented the highest risk for ages 30-79 (IRR 12.08, 95% CI 11.49-12.70) and ≥80 years (IRR 4.03, 95% CI 3.70-4.39). Clinical characteristics significantly modified cardiovascular mortality. Conclusions: Integrating cardiovascular disease CVD monitoring and proactive management into lung cancer treatment protocols is essential to the improvement of overall survival and quality of life for lung cancer patients, particularly those who were young or with advanced tumor stage.

    Keywords: lung cancer, general population, Mortality, cardiovascular disease, incidence rate ratio

    Received: 05 Sep 2024; Accepted: 03 Dec 2024.

    Copyright: © 2024 Wang, Wang, Yang, Zhang, Zhang and Yang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Jing Yang, Sichuan Cancer Hospital, Chengdu, China
    Songbo Zhang, Sichuan Cancer Hospital, Chengdu, China
    Purong Zhang, Sichuan Cancer Hospital, Chengdu, China
    Ye Yang, Sichuan Cancer Hospital, Chengdu, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.