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REVIEW article

Front. Cardiovasc. Med.
Sec. Cardiac Rhythmology
Volume 11 - 2024 | doi: 10.3389/fcvm.2024.1488207

Mitochondrial dysfunction is a key link involved in the pathogenesis of sick sinus syndrome： a review

Provisionally accepted
Xinxin Shi Xinxin Shi 1Liming He Liming He 1Yucheng Wang Yucheng Wang 1Yue Wu Yue Wu 1Dongming Lin Dongming Lin 1Chao Chen Chao Chen 2Shuwei Huang Shuwei Huang 1*Ming Yang Ming Yang 3*
  • 1 First Affiliated Hospital, Zhejiang Chinese Medical University, Hangzhou, China
  • 2 Hangzhou Hospital of Traditional Chinese Medicine, Hangzhou, Zhejiang Province, China
  • 3 Second Affiliated Hospital, Zhejiang Chinese Medical University, Hangzhou, Zhejiang Province, China

The final, formatted version of the article will be published soon.

    Sick sinus syndrome (SSS) is a grave medical condition that can precipitate sudden death. The pathogenesis of SSS remains incompletely understood. Existing research postulates that the fundamental mechanism involves increased fibrosis of the sinoatrial node and its surrounding tissues, as well as disturbances in the coupled-clock system, comprising the membrane clock and the Ca²⁺ clock. Mitochondrial dysfunction exacerbates regional tissue fibrosis and disrupts the functioning of both the membrane and calcium clocks. This plays a crucial role in the underlying pathophysiology of SSS, including mitochondrial energy metabolism disorders, mitochondrial oxidative stress damage, calcium overload, and mitochondrial quality control disorders. Elucidating the mitochondrial mechanisms involved in the pathophysiology of SSS and further investigating the disease's mechanisms is of great significance.

    Keywords: 2+ clock, Fibrosis, Ion channel protein, membrane clock, Mitochondria, review, Sick Sinus Syndrome

    Received: 29 Aug 2024; Accepted: 15 Oct 2024.

    Copyright: © 2024 Shi, He, Wang, Wu, Lin, Chen, Huang and Yang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Shuwei Huang, First Affiliated Hospital, Zhejiang Chinese Medical University, Hangzhou, China
    Ming Yang, Second Affiliated Hospital, Zhejiang Chinese Medical University, Hangzhou, 310005, Zhejiang Province, China

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