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REVIEW article

Front. Cardiovasc. Med.
Sec. Cardiovascular Imaging
Volume 11 - 2024 | doi: 10.3389/fcvm.2024.1479777
This article is part of the Research Topic The Breakthroughs of Functional Imaging in Cardiovascular Diseases View all articles

Recent Advances in Positron Emission Tomography for Detecting Early Fibrosis After Myocardial Infarction

Provisionally accepted
Qiuyan Wu Qiuyan Wu Jialin Song Jialin Song *Wenyan Liu Wenyan Liu *Li Li Li Li *Sijin Li Sijin Li *
  • Shanxi Medical University, Taiyuan, China

The final, formatted version of the article will be published soon.

    Cardiac remodeling after myocardial infarction is one of the key factors affecting patient prognosis. Myocardial fibrosis is an important pathological link of adverse ventricular remodeling after myocardial infarction, and early fibrosis is reversible. Timely detection and intervention can effectively prevent its progression to irreversible ventricular remodeling. Although imaging modalities such as CMR and echocardiography can identify fibrosis, their sensitivity and specificity are limited, and they cannot detect early fibrosis or its activity level. Positron emission tomography (PET) allows non-invasive visualization of cellular and subcellular processes and can monitor and quantify molecules and proteins in the fibrotic pathway. It is valuable in assessing the extent of early myocardial fibrosis progression, selecting appropriate treatments, evaluating response to therapy, and determining the prognosis. In this article, we present a brief overview of mechanisms underlying myocardial fibrosis following myocardial infarction and several routine imaging techniques currently available for assessing fibrosis. Then, we focus on the application of PET molecular imaging in detecting fibrosis after myocardial infarction.

    Keywords: Myocardial Infarction1, myocardial fibrosis2, positron emission tomography3, molecular probes4, fibroblast activation protein5, αvβ36, collagen7, proline8

    Received: 12 Aug 2024; Accepted: 14 Oct 2024.

    Copyright: © 2024 Wu, Song, Liu, Li and Li. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Jialin Song, Shanxi Medical University, Taiyuan, China
    Wenyan Liu, Shanxi Medical University, Taiyuan, China
    Li Li, Shanxi Medical University, Taiyuan, China
    Sijin Li, Shanxi Medical University, Taiyuan, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.