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ORIGINAL RESEARCH article

Front. Cardiovasc. Med.
Sec. Coronary Artery Disease
Volume 11 - 2024 | doi: 10.3389/fcvm.2024.1478743

Correlation between admission blood glucose, fibrinogen, and slow blood flow during primary PCI for acute ST segment elevation myocardial infarction

Provisionally accepted
Wu Zufei Wu Zufei 1Su Wentao Su Wentao 2Shi Chen Shi Chen 3BaiDa Xu BaiDa Xu 2Gang Jun Zong Gang Jun Zong 2Gang-Yong Wu Gang-Yong Wu 2*
  • 1 Xuancheng People's Hospital, Xuancheng, Anhui, China
  • 2 904th Hospital of PLA, Wuxi, Jiangsu Province, China
  • 3 Wuxi No.5 People’s Hospital, Wuxi, Jiangsu Province, China

The final, formatted version of the article will be published soon.

    Backgroud: Coronary slow flow (CSF) is a common phenomenon of coronary microcirculation dysfunction, and is closely related to elevated blood glucose and fibrinogen (FIB) levels. However, whether immediate blood glucose and FIB levels affect coronary blood flow during primary percutaneous coronary intervention (PCI) remains unclear.Objective: To explore the correlation between admission blood glucose (ABG), fibrinogen (FIB) and slow blood flow during primary PCI for acute ST segment elevation myocardial infarction (STEMI).Methods: A total of 497 patients who underwent coronary angiography in the cardiology department of the 904th Hospital of the Joint Logistics Support Force from December 2018 to December 2022 due to STEMI were selected consecutively, and then were divided into two groups based on whether slow blood flow occurred during primary PCI: slow blood flow group (n=117) and control group (n=380). Detecting the ABG, FIB and other indicators of patients in each group, and using logistic regression analysis and receiver operating characteristic (ROC) curve to analyze independent risk factors for slow blood flow during primary PCI, and further evaluating the prognosis of patients.The levels of ABG and FIB in patients with slow blood flow were significantly higher than those in the control group (P<0.05). The results of multivariate logistic regression analysis suggested that FIB and ABG were independent risk factors for slow blood flow during primary PCI (both P<0.05). ROC curve analysis showed that ABG, FIB, and their combination all had predictive value for slow blood flow during primary PCI (all P<0.05), and the area under the curve (AUC) of the combined indicator was higher than that of any single indicator, with statistical significance (P<0.05). KM curve analysis suggested that the prognosis of patients in slow blood flow group were poor.Both elevated ABG and FIB could predict slow blood flow during primary PCI, and the diagnostic value of the combined indicator was superior to that of any single indicator, which could be used for the evaluation of slow blood flow during primary PCI, so as to evaluate the prognosis of patients with STEMI.

    Keywords: Admission blood glucose, Fibrinogen, Acute ST segment elevation myocardial infarction, Percutaneous Coronary Intervention, Slow blood flow

    Received: 12 Aug 2024; Accepted: 14 Nov 2024.

    Copyright: © 2024 Zufei, Wentao, Chen, Xu, Zong and Wu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Gang-Yong Wu, 904th Hospital of PLA, Wuxi, 214000, Jiangsu Province, China

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