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REVIEW article

Front. Cardiovasc. Med.
Sec. Cardiovascular Pharmacology and Drug Discovery
Volume 11 - 2024 | doi: 10.3389/fcvm.2024.1477636
This article is part of the Research Topic Exploring Molecular Mechanisms and Novel Diagnostics in Cardiovascular Disease Treatment View all 7 articles

Research progress of sea buckthorn (Hippophae rhamnoides L.) in prevention and treatment of cardiovascular disease

Provisionally accepted
Yumeng Chen Yumeng Chen 1Weiwei He Weiwei He 2Hanjing Cao Hanjing Cao 1Zhenzhen Wang Zhenzhen Wang 3Jiping Liu Jiping Liu 1Bin Wang Bin Wang 4Chuan Wang Chuan Wang 1*
  • 1 Department of Pharmacology, Shaanxi University of Chinese Medicine, Xianyang, China
  • 2 Department of Physiology, Shaanxi University of Chinese Medicine, Xianyang, China
  • 3 Department of Nursing, Shaanxi University of Chinese Medicine, Xianyang, China
  • 4 Department of Pharmacology, Shaanxi University of Chinese Medicine, Xianyang, China

The final, formatted version of the article will be published soon.

    Sea buckthorn (Hippophae rhamnoides L.) contains a variety of biologically active compounds, including flavonoids, terpenoids, polysaccharides, organic acids, volatile oils, and vitamins. It has been demonstrated to be effective in the treatment of cardiovascular disorders. In this paper, we evaluated the pharmacological effects of sea buckthorn in cardiovascular diseases through preclinical studies, and revealed the mechanism of action of the active components in sea buckthorn in cardiovascular diseases, including anti-inflammatory, lipid oxidation regulation, antioxidant, vascular function modulation, anti-platelet aggregation, autophagy, intestinal microorganism regulation, and cell apoptosis reduction. In clinical trials, sea buckthorn was proven to be effective in managing lipid metabolism, blood pressure, and blood glucose levels in patients. We also extensively reviewed the safety of sea buckthorn medicine and its toxicity to numerous organs. To summarize, sea buckthorn has a beneficial effect on cardiovascular disease and may give a novel strategy for clinical intervention and therapy. This paper summarizes the phytochemistry, pharmacology, clinical applications, safety, and toxicity of sea buckthorn in order to better understand the mechanism of action of the various bioactive components in sea buckthorn, investigate its medicinal potential, and provide more options for the treatment of cardiovascular diseases.

    Keywords: sea buckthorn, phytochemistry, Pharmacology, clinical application, cardiovascular disease

    Received: 08 Aug 2024; Accepted: 07 Oct 2024.

    Copyright: © 2024 Chen, He, Cao, Wang, Liu, Wang and Wang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Chuan Wang, Department of Pharmacology, Shaanxi University of Chinese Medicine, Xianyang, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.