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REVIEW article

Front. Cardiovasc. Med.
Sec. Cardiovascular Pharmacology and Drug Discovery
Volume 11 - 2024 | doi: 10.3389/fcvm.2024.1477601

Chinese and Western medicine treatment of myocardial fibrosis drugs

Provisionally accepted
Yuxi Zhu Yuxi Zhu 1Fangmei Zhang Fangmei Zhang 2*Zhongcheng Li Zhongcheng Li 3*Yu Zhou Yu Zhou 3*Yi Shu Yi Shu 3*Jian Ruan Jian Ruan 1*Guo Chen Guo Chen 3*
  • 1 Graduate School, Jiangxi University of Chinese Medicine, Nanchang, Jiangxi, China
  • 2 The 334 Affiliated Hospital of Nanchang University, Nanchang, Jiangxi Province, China
  • 3 Bao'an Authentic TCM Therapy Hospital, Shenzheng, China

The final, formatted version of the article will be published soon.

    Myocardial fibrosis (MF) is a common pathological manifestation of many cardiovascular diseases, such as myocardial infarction, myocardial ischemia, and sudden cardiac death. It is characterized by excessive proliferation and activation of fibroblasts, transformation into myofibroblasts, and eventually excessive deposition of the extracellular matrix, resulting in heart damage. Currently, modern drugs such as angiotensin-converting enzyme inhibitors, diuretics, and β-blockers can improve myocardial fibrosis in clinical treatment, but the therapeutic effect on this disease is limited, with obvious side effects and high cost.Traditional Chinese medicine (TCM) has the advantages of multiple targets, low cost, and few side effects.Traditional Chinese medicines, such as Salvia miltiorrhiza, Astragalus, and Angelica extracts, and Chinese patent medicines, such as Qiliqiangxin capsules, Shenqi Yiqi dropping pills, and Tongxinluo capsules, can improve myocardial fibrosis. In this review, the current treatment methods for myocardial fibrosis in Chinese and Western medicine are discussed. The signaling pathways and targets of Chinese and Western

    Keywords: Myocardial fibrosis, Western medicine, Chinese medicine, drugs, Excessive extracellular matrix

    Received: 08 Aug 2024; Accepted: 16 Dec 2024.

    Copyright: © 2024 Zhu, Zhang, Li, Zhou, Shu, Ruan and Chen. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Fangmei Zhang, The 334 Affiliated Hospital of Nanchang University, Nanchang, Jiangxi Province, China
    Zhongcheng Li, Bao'an Authentic TCM Therapy Hospital, Shenzheng, China
    Yu Zhou, Bao'an Authentic TCM Therapy Hospital, Shenzheng, China
    Yi Shu, Bao'an Authentic TCM Therapy Hospital, Shenzheng, China
    Jian Ruan, Graduate School, Jiangxi University of Chinese Medicine, Nanchang, Jiangxi, China
    Guo Chen, Bao'an Authentic TCM Therapy Hospital, Shenzheng, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.