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ORIGINAL RESEARCH article

Front. Cardiovasc. Med.
Sec. Lipids in Cardiovascular Disease
Volume 11 - 2024 | doi: 10.3389/fcvm.2024.1473171

Sex-specific differences in the association between triglyceride glucose index and carotid plaque in a cardiovascular high-risk population：a cross-sectional study based on a Chinese community-dwelling population

Provisionally accepted
Weiguo Lin Weiguo Lin 1Mengjie Xu Mengjie Xu 2Jinbiao Zheng Jinbiao Zheng 1Ruixue Sun Ruixue Sun 1Shaorong Shaorong Yan Shaorong Shaorong Yan 1Xiaoshu Chen Xiaoshu Chen 2Yuzhan L Yuzhan L 1*
  • 1 Third Affiliated Hospital of Wenzhou Medical University, Wenzhou, China
  • 2 Wenzhou People’s Hospital, Wenzhou, Zhejiang Province, China

The final, formatted version of the article will be published soon.

    Background: To date, numerous studies have investigated the relationship between the triglyceride glucose (TyG) index and carotid plaques, but the impact of gender on this relationship has not been explored. Therefore, this study aims to investigate gender-specific differences in the relationship between the TyG index and carotid plaques in a high cardiovascular risk population in China. Methods: This cross-sectional study's data were derived from a longitudinal pilot study involving 1,085 high-risk cardiovascular subjects. A multivariable logistic regression model was used to analyze the relationship between the TyG index and carotid plaques. A generalized additive model combined with a stratified regression model was employed to assess the nonlinear relationship between the TyG index and carotid plaques across different genders. In the nonlinear relation, the inflection point was calculated by a two-piecewise linear regression model. Results: After adjusting for confounders such as age, sex, BMI, SBP, DBP, AST/ALT, TC, LDL-c, HDL-c, creatinine, smoking, and antilipemic medication, the generalized additive model results revealed a nonlinear relationship between the TyG index and carotid plaque formation, with significant differences across genders. In males, the relationship between the TyG index and carotid plaques was S-shaped. The two-piecewise linear regression model identified two inflection points: TyG = 8.39 (P = 0.017) and TyG = 10.2 (P = 0.009). Conclusion: The relationship between the TyG index and the formation of carotid plaques is nonlinear, and there are significant differences in the correlation between males and females.

    Keywords: Triglyceride glucose index, carotid plaque, sex differences, cardiovascular risk, Generalized additive model

    Received: 30 Jul 2024; Accepted: 29 Sep 2024.

    Copyright: © 2024 Lin, Xu, Zheng, Sun, Shaorong Yan, Chen and L. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Yuzhan L, Third Affiliated Hospital of Wenzhou Medical University, Wenzhou, China

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