Skip to main content

ORIGINAL RESEARCH article

Front. Cardiovasc. Med.
Sec. Atherosclerosis and Vascular Medicine
Volume 11 - 2024 | doi: 10.3389/fcvm.2024.1471479

Influence of remnant lipoprotein particle cholesterol on non-target lesions progression in patients undergoing percutaneous coronary intervention

Provisionally accepted
Jing Liu Jing Liu 1Tian-Qi Teng Tian-Qi Teng 1Zheng Li Zheng Li 1Feng-Wang Hu Feng-Wang Hu 1Wei-Wei Sha Wei-Wei Sha 2Chang-Xian Shen Chang-Xian Shen 1Yong Xia Yong Xia 2Yao-Jun Zhang Yao-Jun Zhang 1,2Li Liang Li Liang 1,2*
  • 1 Xu Zhou New Health Geriatric Hospital, xuzhou, China
  • 2 Xuzhou Medical University, Xuzhou, Jiangsu Province, China

The final, formatted version of the article will be published soon.

    Background: Low-Density Lipoprotein Cholesterol (LDL-C) is the primary lipid therapy target for coronary artery disease (CAD) patients after percutaneous coronary intervention (PCI). However, progression of coronary atherosclerosis occurs even LDL-C controlled well，some potentially important factors have been overlooked.Objective：This study aims to elucidate the relationship between remnant lipoprotein particle cholesterol (RLP-C) and the progression of non-target lesions (NTLs) in patients with well-controlled lipid levels after PCI.Methods: This retrospective study included 769 CAD patients who underwent PCI and followed up angiography within 6 to 24 months thereafter. Employing Multivariate Cox regression analysis, we assessed the correlation between RLP-C and NTLs progression.Based on the receiver operating characteristic curve analysis, we identified the optimal cutoff point for RLP-C, following which the patients were divided into two groups.Propensity score matching balanced confounding factors between groups, and Log-rank tests compared Kaplan-Meier curves for overall follow-up to assess NTLs progression.Results: Multivariate Cox analysis revealed an independent association between RLP-C and NTLs progression when LDL-C was well-controlled. Additionally, the RLP-C level of 0.555 mmol/L was determined to be the best value for predicting NTLs progression. Following propensity score matching, Kaplan-Meier curves illustrated a significantly higher cumulative rate of NTLs progression in patients with RLP-C levels ≥0.555 mmol/L compared to the others (Log-rank P=0.002). Elevated RLP-C levels were associated with high triglyceride concentrations, diabetes mellitus, and increased risk of revascularization.Conclusions: This study illustrated the atherogenic impact of RLP-C in CAD patients.High RLP-C levels increased the risk of revascularization.

    Keywords: Atherosclerosis, Percutaneous Coronary Intervention, Remnant lipoprotein particle cholesterol, Triglyceride-rich lipoproteins, Non-target lesion

    Received: 27 Jul 2024; Accepted: 28 Nov 2024.

    Copyright: © 2024 Liu, Teng, Li, Hu, Sha, Shen, Xia, Zhang and Liang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Li Liang, Xuzhou Medical University, Xuzhou, 221004, Jiangsu Province, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.