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ORIGINAL RESEARCH article

Front. Cardiovasc. Med.
Sec. Atherosclerosis and Vascular Medicine
Volume 11 - 2024 | doi: 10.3389/fcvm.2024.1469730

The correlation between serum MHR and NLR and the severity of coronary lesions in NSTE-ACS patients of different genders

Provisionally accepted
Yanping Yang Yanping Yang 1Xiaobing Lv Xiaobing Lv 1Tan Kai Tan Kai 1Kai Li Kai Li 1Shaohua Li Shaohua Li 1Xia Meng Xia Meng 2Yunyun Chen Yunyun Chen 2Fuqing Wang Fuqing Wang 2Hui Xin Hui Xin 1*
  • 1 The Affiliated Hospital of Qingdao University, Qingdao, Shandong Province, China
  • 2 qingdao west coast new area central hospital, Qingdao, China

The final, formatted version of the article will be published soon.

    To study the relationship between the monocyte/high-density lipoprotein cholesterol ratio (MHR) and neutrophil-to-lymphocyte ratio (NLR) and coronary artery stenosis in Non-st-elevation acute coronary syndromes (NSTE-ACS) patients of different genders.A total of 253 control and 800 NSTE-ACS patients were included, and clinic data (29 items) were also collected. NSTE-ACS patients were divided into low-risk (0-23) and high-risk (≥ 23) groups based on the Synergy between PCI with Taxus and Cardiac Surgery (SYNTAX) score. Then, Spearman correlation and multivariate logistic regression analyses were performed to study the associated factors of high-risk SYNTAX score in male and female NSTE-ACS patients, respectively. Finally, the receiver operating characteristic (ROC) curve was used to calculate the diagnostic value of MHR and NLR for predicting high-risk SYNTAX scores in male NSTE-ACS patients.Sixteen distinct factors differed between the high-and low-risk groups in male NSTE-ACS patients, a significantly higher number than female NSTE-ACS patients.Gout/hyperuricemia, smoking, NLR, and MHR are independent risk factors for arterial stenosis. At the same time, high-density lipoprotein and left ventricular ejection fraction (LVEF) are found to be protective factors in male NSTE-ACS patients. Fibrinogen, apolipoprotein B/A, and neutrophils are identified as independent risk factors for arterial stenosis in female NSTE-ACS patients, while LVEF and high-density lipoprotein are protective factors. Finally, combined NLR and MHR (p = 0.000, 95% confidence interval (CI) = 0.726-0.810) had better predictive efficacy on the degree of arterial vessel stenosis than NLR or MHR alone. The sensitivity and specificity of the ROC curve were 0.672 and 0.769, respectively.The combination of MHR and NLR shows potential for predicting and assessing the severity of coronary artery stenosis in male patients with NSTE-ACS.

    Keywords: Non ST-elevation acute coronary syndrome, Monocyte/high-density lipoprotein cholesterol ratio (MHR), Neutrophil to lymphocyte ratio (NLR), Syntax score, receiver operating characteristic (ROC)

    Received: 24 Jul 2024; Accepted: 24 Dec 2024.

    Copyright: © 2024 Yang, Lv, Kai, Li, Li, Meng, Chen, Wang and Xin. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Hui Xin, The Affiliated Hospital of Qingdao University, Qingdao, 266000, Shandong Province, China

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