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REVIEW article

Front. Cardiovasc. Med.
Sec. Cardiovascular Metabolism
Volume 11 - 2024 | doi: 10.3389/fcvm.2024.1469492

Drivers of cardiovascular disease in Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) The threats of oxidative stress

Provisionally accepted
Erika T. Minetti Erika T. Minetti Naomi M. Hamburg Naomi M. Hamburg Reiko Matsui Reiko Matsui *
  • Boston University, Boston, United States

The final, formatted version of the article will be published soon.

    Non-alcoholic fatty liver disease (NAFLD), now known as metabolic-associated steatotic liver disease (MASLD), is the most common liver disease worldwide, with a prevalence of 38%. In these patients, cardiovascular disease (CVD) is the number one cause of mortality rather than liver disease. Liver abnormalities per se due to MASLD contribute to risk factors such as dyslipidemia and obesity and increase CVD incidents. In this review we discuss hepatic pathophysiological changes the liver of MASLD leading to cardiovascular risks, including liver sinusoidal endothelial cells, insulin resistance, and oxidative stress with a focus on glutathione metabolism and function. In an era where there is an increasingly robust recognition of what causes CVD, such as the factors included by the American Heart Association in the recently developed PREVENT equation, the inclusion of liver disease may open doors to how we approach treatment for MASLD patients who are at risk of CVD.

    Keywords: cardiovascular risk, steatosis, MASLD, Liver sinusoid, Insulin Resistance, Glutathione, Oxidative Stress

    Received: 23 Jul 2024; Accepted: 30 Aug 2024.

    Copyright: © 2024 Minetti, Hamburg and Matsui. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Reiko Matsui, Boston University, Boston, United States

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.