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ORIGINAL RESEARCH article

Front. Cardiovasc. Med.
Sec. Lipids in Cardiovascular Disease
Volume 11 - 2024 | doi: 10.3389/fcvm.2024.1469433
This article is part of the Research Topic Evidence of Atherogenic Lipoproteins: what we gain from in vitro and in vivo research View all 7 articles

Effect of Bariatric Surgery on HDL-Mediated Cholesterol Efflux Capacity

Provisionally accepted
Olga Castaner Olga Castaner 1,2,3*Karla A. Perez-Vega Karla A. Perez-Vega 4,5Sara Alvarez Sara Alvarez 2,6Susana Vazquez Susana Vazquez 6,7Anna Casajoana Anna Casajoana 7,8Gemma Blanchart Gemma Blanchart 7Sonia Gaixas Sonia Gaixas 7Helmut Schroder Helmut Schroder 3,7Dolores Zomeño-Fajardo Dolores Zomeño-Fajardo 5,7,9Isaac Subirana Isaac Subirana 10,7Daniel Muñoz-Aguayo Daniel Muñoz-Aguayo 5,7Montserrat Fito Montserrat Fito 5,7David Benaiges David Benaiges 11,12,7Albert Goday Albert Goday 11,13,7Anna Oliveras Anna Oliveras 14,15,7
  • 1 Fundació Institut Mar d'Investigacions Mèdiques (IMIM), Barcelona, Spain
  • 2 Hospital del Mar Medical Research Institute (IMIM), Barcelona, Catalonia, Spain
  • 3 Center for Biomedical Research in Epidemiology and Public Health Network, Carlos III Health Institute (ISCIII), Madrid, Madrid, Spain
  • 4 Cardiovascular Risk and Nutrition Research group, Hospital del Mar Medical Research Institute (IMIM), Barcelona, Catalonia, Spain
  • 5 CIBER Fisiopatología Obesidad y Nutrición (CIBEROBN), Madrid, Madrid, Spain
  • 6 Nephrology Deparment, Hospital del Mar, Barcelona, Balearic Islands, Spain
  • 7 Hospital del Mar Research Institute (IMIM), Barcelona, Spain
  • 8 General Surgery Service, Hospital del Mar, Barcelona, Spain
  • 9 Ramon Llull University, Barcelona, Catalonia, Spain
  • 10 Biomedical Network Research Center on Cardiovascular Diseases, Carlos III Health Institute (ISCIII), Madrid, Madrid, Spain
  • 11 Department of Endocrinology and Nutrition. Hospital del Mar, Barcelona, Spain
  • 12 Consorci Sanitari de l´Alt Penedès-Garraf, Vilafranca del Penedès, Spain
  • 13 Autonomous University of Barcelona, Barcelona, Catalonia, Spain
  • 14 Nephrology Department, Hospital del Mar, Barcelona, Spain
  • 15 Department of Medicine, Universitat Pompeu Fabra, Barcelona, Spain

The final, formatted version of the article will be published soon.

    This original research meets the scope of the research topic "Evidence of atherogenic lipoproteins, what we gain from in vitro and in vivo research." as it focus on the qualitative properties of HDL in patients with obesity treated with bariatric surgery for severe obesity. We performed exvivo invitro cell culture studies to assess the cholesterol efflux capacity and antiinflamatory ability of HDL. We also searched for asociations between the different obesity characteristics with different HDL functions. The effect of a rapid weight loss on the lipid profile and specific qualitative aspects of HDL capacity gives added information on the antiatherogenic mechanisms on patients with obesity affected of low chronic inflammation.

    Keywords: Anna Casajoana: Methodology, Writing -review & editing. Albert Goday: Conceptualization, Funding acquisition, methodology, supervision, Writing -review & editing. Anna Oliveras: Conceptualization, Data curation, Validation

    Received: 23 Jul 2024; Accepted: 10 Oct 2024.

    Copyright: © 2024 Castaner, Perez-Vega, Alvarez, Vazquez, Casajoana, Blanchart, Gaixas, Schroder, Zomeño-Fajardo, Subirana, Muñoz-Aguayo, Fito, Benaiges, Goday and Oliveras. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Olga Castaner, Fundació Institut Mar d'Investigacions Mèdiques (IMIM), Barcelona, Spain

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.