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ORIGINAL RESEARCH article

Front. Cardiovasc. Med.
Sec. Lipids in Cardiovascular Disease
Volume 11 - 2024 | doi: 10.3389/fcvm.2024.1462142

Correlation between Remnant Cholesterol and Premature Coronary Artery Disease and the Severity of Coronary Artery Lesions in Men: A Retrospective Study

Provisionally accepted
Xingming Dong Xingming Dong 1*Ke Chen Ke Chen 2Xiuqin Li Xiuqin Li 1Yuanyuan Tang Yuanyuan Tang 2Rui Zhang Rui Zhang 1Jian Wang Jian Wang 1
  • 1 Weifang People's Hospital, Weifang, China
  • 2 Second People’s Hospital of Weifang, Weifang, Shandong Province, China

The final, formatted version of the article will be published soon.

    Objective: To investigate the correlation between remnant cholesterol (RC) and premature coronary artery disease (PCAD) and the severity of coronary artery lesions in men.Methods: A total of 630 male subjects who underwent coronary angiography were included in the study. The general data, laboratory tests, and coronary angiography data of each group were statistically analyzed, and RC levels were calculated. According to the Gensini score, PCAD was divided into mild and severe lesion groups. The relationship between RC and PCAD and coronary artery lesions was analyzed using multivariate logistic regression and spearman correlation analysis, and the predictive value of RC for coronary artery lesions was evaluated using receiver operating characteristic (ROC) curves.The RC levels in the PCAD group were significantly higher than those in the non-PCAD group (p<0.05), and RC was an independent risk factor for PCAD (p<0.05).The RC levels in the severe lesion group were higher than those in the mild lesion group (p<0.05), and RC levels were positively correlated with the Gensini score (r=0.335, p<0.001).Multivariate logistic regression analysis showed that RC was an independent risk factor for severe coronary artery lesions (p<0.05).The ROC curve calculated the value of RC in predicting severe coronary artery lesions, with an area under the curve of 0.693, a cutoff value of 0.485 mmol/L, a sensitivity of 64.7%, and a specificity of 66.2%. Conclusion: RC is an independent risk factor for PCAD and the severity of coronary artery lesions in adult men. RC levels are positively correlated with the severity of coronary artery lesions and can be used as an auxiliary indicator for clinical assessment of PCAD.

    Keywords: Premature coronary artery disease, Remnant cholesterol, Coronary artery lesions, Gensini score, Retrospective study

    Received: 09 Jul 2024; Accepted: 13 Nov 2024.

    Copyright: © 2024 Dong, Chen, Li, Tang, Zhang and Wang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Xingming Dong, Weifang People's Hospital, Weifang, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.