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BRIEF RESEARCH REPORT article

Front. Cardiovasc. Med.
Sec. Atherosclerosis and Vascular Medicine
Volume 11 - 2024 | doi: 10.3389/fcvm.2024.1462032

The C57BL/6N mouse substrain is a viable model of elastaseinduced abdominal aortic aneurysm

Provisionally accepted
Panpan Wei Panpan Wei 1Kexin Li Kexin Li 1Meng Li Meng Li 2Liu Haole Liu Haole 1Congcong Xia Congcong Xia 1Yajie Chen Yajie Chen 3Sihai Zhao Sihai Zhao 1Yankui Li Yankui Li 2*
  • 1 Xi'an Jiaotong University, Xi'an, China
  • 2 Tianjin Medical University, Tianjin, Tianjin Municipality, China
  • 3 School of Pharmacy and Food Engineering, Wuyi University, Jiangmen, China

The final, formatted version of the article will be published soon.

    Aim: Compared with the C57BL/6N substrain, the C57BL/6J substrain is more susceptible to the angiotensin II (Ang II)-induced development of dissected abdominal aortic aneurysms (AAAs). The aim of this study was to elucidate whether the widely used C57BL/6N mouse substrain is as susceptible as the C57BL/6J mouse substrain to porcine pancreatic elastase (PPE) infusion-induced experimental nondissected AAA development.Method: Experimental nondissected AAAs were induced in C57BL/6J and C57BL/6N mice via transient aortic luminal infusion of PPE. On Day 0 (baseline) and Day 14 after PPE infusion, the abdominal aortic diameter was directly measured. Aortic aneurysmal segment samples were collected, and histopathological analysis was performed.Results: On Day 14 after PPE infusion, aortic diameters were significantly increased in both mouse substrains (from approximately 0.51 to 1.

    Keywords: Abdominal Aortic Aneurysm, Smooth Muscle Cell, Inflammation, Elastin, animal model

    Received: 23 Jul 2024; Accepted: 19 Sep 2024.

    Copyright: © 2024 Wei, Li, Li, Haole, Xia, Chen, Zhao and Li. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Yankui Li, Tianjin Medical University, Tianjin, 300070, Tianjin Municipality, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.