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CASE REPORT article
Front. Cardiovasc. Med.
Sec. Atherosclerosis and Vascular Medicine
Volume 11 - 2024 |
doi: 10.3389/fcvm.2024.1460708
Case Report: The application of Novel Imaging Technologies for Lower Extremity Peripheral Artery Disease: NIR-II Imaging, OCTA and LSFG
Provisionally accepted- 1 Department of Vascular Surgery, Second Hospital of Shanxi Medical University, Taiyuan, China
- 2 Key Laboratory of Big Data-Based Precision Medicine of Ministry of Industry and Information Technology, School of Engineering Medicine, Beihang University, Beijing, Beijing Municipality, China
- 3 Department of Nephrology, Second Hospital of Shanxi Medical University, Taiyuan, China
Lower extremity peripheral artery disease (PAD) is a growing global health problem.New ways have been explored to diagnose PAD in recent years. At present, most of imaging methods for PAD focus on the macrovascular blood flow, and the exploration of microcirculation and tissue perfusion of PAD remains largely insufficient. In this report, we applied three new imaging technologies, second near-infrared region (NIR-II, 900-1,880 nm wavelengths) imaging, optical coherence tomography angiography (OCTA) and laser speckle flowgraphy (LSFG) in a PAD patient with a healthy human subject as control. Our results showed that the PAD patient had poorer tissue perfusion than the control without adverse effects observed. Moreover, compared with the first near-infrared region (NIR-I, 700-900 nm wavelengths) imaging results, NIR-II imaging showed higher signal-to-background ratio (SBR) and resolution than NIR-I imaging, and detected microvessels that were not detected by NIR-I imaging. These observations suggested that NIR-II imaging, OCTA and LSFG were potential safe and effective methods for diagnosing PAD.
Keywords: peripheral artery disease, NIR-II imaging, Optical Coherence Tomography, Laser speckle flowgraphy, Imaging technology
Received: 06 Jul 2024; Accepted: 27 Aug 2024.
Copyright: © 2024 Ning, Jie, Li, Lu, Zhang, Yan, Shi, Gao, Wang, Zhang and Dong. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Haifeng Li, Department of Vascular Surgery, Second Hospital of Shanxi Medical University, Taiyuan, China
Peilu Shi, Department of Vascular Surgery, Second Hospital of Shanxi Medical University, Taiyuan, China
Ruijing Zhang, Department of Nephrology, Second Hospital of Shanxi Medical University, Taiyuan, China
Honglin Dong, Department of Vascular Surgery, Second Hospital of Shanxi Medical University, Taiyuan, China
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