Skip to main content

CASE REPORT article

Front. Cardiovasc. Med.
Sec. Atherosclerosis and Vascular Medicine
Volume 11 - 2024 | doi: 10.3389/fcvm.2024.1460708
This article is part of the Research Topic New Trends in Vascular Biology 2024 View all 10 articles

Case Report: The application of Novel Imaging Technologies for Lower Extremity Peripheral Artery Disease: NIR-II Imaging, OCTA and LSFG

Provisionally accepted
Yijie Ning Yijie Ning 1Hu Jie Hu Jie 1Haifeng Li Haifeng Li 1*Chuanlong Lu Chuanlong Lu 1Zeyu Zhang Zeyu Zhang 2Sheng Yan Sheng Yan 1Peilu Shi Peilu Shi 1*Tingting Gao Tingting Gao 1Heng Wang Heng Wang 1Ruijing Zhang Ruijing Zhang 3*Honglin Dong Honglin Dong 1*
  • 1 Department of Vascular Surgery, Second Hospital of Shanxi Medical University, Taiyuan, China
  • 2 Key Laboratory of Big Data-Based Precision Medicine of Ministry of Industry and Information Technology, School of Engineering Medicine, Beihang University, Beijing, Beijing Municipality, China
  • 3 Department of Nephrology, Second Hospital of Shanxi Medical University, Taiyuan, China

The final, formatted version of the article will be published soon.

    Lower extremity peripheral artery disease (PAD) is a growing global health problem.New ways have been explored to diagnose PAD in recent years. At present, most of imaging methods for PAD focus on the macrovascular blood flow, and the exploration of microcirculation and tissue perfusion of PAD remains largely insufficient. In this report, we applied three new imaging technologies, second near-infrared region (NIR-II, 900-1,880 nm wavelengths) imaging, optical coherence tomography angiography (OCTA) and laser speckle flowgraphy (LSFG) in a PAD patient with a healthy human subject as control. Our results showed that the PAD patient had poorer tissue perfusion than the control without adverse effects observed. Moreover, compared with the first near-infrared region (NIR-I, 700-900 nm wavelengths) imaging results, NIR-II imaging showed higher signal-to-background ratio (SBR) and resolution than NIR-I imaging, and detected microvessels that were not detected by NIR-I imaging. These observations suggested that NIR-II imaging, OCTA and LSFG were potential safe and effective methods for diagnosing PAD.

    Keywords: peripheral artery disease, NIR-II imaging, Optical Coherence Tomography, Laser speckle flowgraphy, Imaging technology

    Received: 06 Jul 2024; Accepted: 27 Aug 2024.

    Copyright: © 2024 Ning, Jie, Li, Lu, Zhang, Yan, Shi, Gao, Wang, Zhang and Dong. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Haifeng Li, Department of Vascular Surgery, Second Hospital of Shanxi Medical University, Taiyuan, China
    Peilu Shi, Department of Vascular Surgery, Second Hospital of Shanxi Medical University, Taiyuan, China
    Ruijing Zhang, Department of Nephrology, Second Hospital of Shanxi Medical University, Taiyuan, China
    Honglin Dong, Department of Vascular Surgery, Second Hospital of Shanxi Medical University, Taiyuan, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.