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ORIGINAL RESEARCH article

Front. Cardiovasc. Med.
Sec. Cardiovascular Epidemiology and Prevention
Volume 11 - 2024 | doi: 10.3389/fcvm.2024.1459062
This article is part of the Research Topic Exploring the Potential for Advancements in Spinal Neurosurgery: Revolutionizing Treatment Pathways and Improving Quality of Life View all 12 articles

Association between arteriosclerosis index and lumbar bone mineral density in U.S adults: A cross-sectional study from the NHANES 2011-2018

Provisionally accepted
Chengxin Xie Chengxin Xie 1Yu Ren Yu Ren 1Qiang He Qiang He 2Chenglong Wang Chenglong Wang 1Hua Luo Hua Luo 1*
  • 1 Taizhou Hospital, Wenzhou Medical University, Linhai, China
  • 2 Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, Shandong Province, China

The final, formatted version of the article will be published soon.

    The arteriosclerosis index, defined as the ratio of non-high density lipoprotein cholesterol to high density lipoprotein cholesterol (NHHR), has emerged as a novel biomarker for various diseases. The relationship between NHHR and lumbar bone mineral density (BMD) has not been previously examined.This cross-sectional study analyzed data from the National Health and Nutrition Examination Survey (NHANES) 2011-2018. NHHR was calculated as (total cholesterolhighdensity lipoprotein cholesterol) / high-density lipoprotein cholesterol. Lumbar BMD was calculated to Z scores. Weighted multivariate linear regression, subgroup analysis, interaction analysis, generalized additive model, and two-piecewise linear regression were used.Results: A total of 8,602 participants were included. The negative association between NHHR and lumbar BMD was consistent and significant (Model 1: β = -0.039, 95% CI: -0.055, -0.023, p <0.001; Model 2: β = -0.045, 95% CI: -0.062, -0.027, p <0.001; Model 3: β = -0.042, 95% CI: -0.061, -0.023, p <0.001). The linear relationship between NHHR and lumbar BMD was significantly influenced by body mass index (p for interaction = 0.012) and hypertension (p for interaction = 0.047). Non-linear associations between NHHR and lumbar BMD Z scores were observed in specific populations, including U-shaped, reverse U-shaped, L-shaped, reverse L-shaped, and U-shaped relationships among menopausal females, underweight participants, those with impaired glucose tolerance, those with diabetes mellitus and those taking anti-hyperlipidemic drugs, respectively.Conclusions: NHHR exhibited a negative association with lumbar BMD, but varying across specific populations. These findings suggest that NHHR should be tailored to individual levels to mitigate 3 bone loss through a personalized approach. Individuals at heightened risk of cardiovascular disease should focus on their bone health.

    Keywords: arteriosclerosis index, NHHR, Lipid ratio, bone mineral density, Adult, NHANES

    Received: 09 Jul 2024; Accepted: 23 Jul 2024.

    Copyright: © 2024 Xie, Ren, He, Wang and Luo. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Hua Luo, Taizhou Hospital, Wenzhou Medical University, Linhai, China

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