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ORIGINAL RESEARCH article

Front. Cardiovasc. Med.
Sec. Coronary Artery Disease
Volume 11 - 2024 | doi: 10.3389/fcvm.2024.1458120
This article is part of the Research Topic Advances and Dilemmas in Contemporary Management of Chronic Coronary Syndrome: Balancing Coronary Revascularization and Conservative Therapy View all articles

Heart failure biomarkers in revascularized patients with stable coronary heart disease as clinical outcome predictors

Provisionally accepted
Ivica Bosnjak Ivica Bosnjak 1Drazen Bedekovic Drazen Bedekovic 1Kristina Selthofer-Relatić Kristina Selthofer-Relatić 1,2Hrvoje Roguljic Hrvoje Roguljic 1,3,4Ivica Mihaljevic Ivica Mihaljevic 5,6,7Darko Dukic Darko Dukic 8Ines Bilic Curcic Ines Bilic Curcic 3,9*
  • 1 Department of Cardiovascular Diseases, Osijek Clinical Hospital Center, Osijek, Croatia
  • 2 Department of Pathophysiology, Faculty of Medicine, Josip Juraj Strossmayer University of Osijek, Osijek, Croatia
  • 3 Department of Pharmacology, Faculty of Medicine, Josip Juraj Strossmayer University of Osijek, Osijek, Croatia
  • 4 Department of Pharmacology and Biochemistry, Faculty of Dental Medicine and Health, Josip Juraj Strossmayer University of Osijek, Osijek, Croatia
  • 5 Academy of Medical Sciences of Croatia, Zagreb, Croatia
  • 6 Department for Nuclear Medicine and Oncology, Faculty of Medicine, Josip Juraj Strossmayer University of Osijek, Osijek, Croatia
  • 7 Clinical Institute of Nuclear Medicine and Radiation Protection, Osijek Clinical Hospital Center, Osijek, Croatia
  • 8 Department of Physics, Josip Juraj Strossmayer University of Osijek, Osijek, Croatia
  • 9 Department of Endocrinology and Metabolism Disorders, Clinical Hospital Center Osijek, Osijek, Croatia

The final, formatted version of the article will be published soon.

    The aim of this study was to investigate serum levels of galectin-3 (Gal-3) and N-terminal pro-brain Natriuretic Peptide (NT-proBNP) in patients with stable obstructive coronary artery disease, as well as their potential to predict clinical outcomes. Methods. This was a single-center cross-sectional cohort study. 168 patients were divided into three groups: percutaneous coronary intervention (PCI) group (N 64), coronary artery bypass graft surgery (CABG) group (N 57), and group with no coronary stenosis (N 47). Gal-3 and NT-proBNP levels were measured and the Syntax score (Ss) was calculated. Results: The mean value of Gal-3 was 19.98 ng/ml and 9.51 ng/ml (p<0.001) in the study group and control group, respectively. Highest value of Gal-3 was found in the group of subjects with three-vessel disease (p<0.001). The mean value of NT-proBNP in the study group was 401.3 pg/ml, and in the control group 100.3pg/ml (p=0.159). The highest value of NT-proBNP was found in the group of subjects with three-vessel disease (p=0.021). There was a statistically significant association between Gal-3, NT-proBNP and occurrence of adverse cardiovascular event (p=0.0018; p=0.0019). Conclusion. Gal-3 and NT-proBNP could be used as an additional tool for diagnosis and severity assessment of stable obstructive coronary artery disease. Furthermore, it could help identify high-risk patients who could experience major adverse cardiovascular events.

    Keywords: galectin-3, NT-ProBNP, Coronary Artery Disease, biomarker, Chronic coronary syndrome, Cardiac outcome

    Received: 01 Jul 2024; Accepted: 27 Aug 2024.

    Copyright: © 2024 Bosnjak, Bedekovic, Selthofer-Relatić, Roguljic, Mihaljevic, Dukic and Bilic Curcic. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Ines Bilic Curcic, Department of Pharmacology, Faculty of Medicine, Josip Juraj Strossmayer University of Osijek, Osijek, Croatia

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