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ORIGINAL RESEARCH article

Front. Cardiovasc. Med.
Sec. Cardiovascular Epidemiology and Prevention
Volume 11 - 2024 | doi: 10.3389/fcvm.2024.1457534
This article is part of the Research Topic Blood Biomarkers in Cardiovascular Diseases View all 6 articles

The levels of systemic inflammatory markers exhibit a positive correlation with the occurrence of heart failure: A cross-sectional study from NHANES

Provisionally accepted
Lei Huang Lei Huang 1*Ronghuan Shen Ronghuan Shen 2Hailan Yu Hailan Yu 3Nake Jin Nake Jin 1Jun Hong Jun Hong 1Yu Luo Yu Luo 1Xudong Chen Xudong Chen 1Jiacheng Rong Jiacheng Rong 1*
  • 1 Ningbo Hangzhou Bay Hospital, Ningbo, China
  • 2 The First Affiliated Hospital of Ningbo University, Ningbo, China
  • 3 Ningbo Medical Centre Lihuili Hospital, Ningbo, Zhejiang Province, China

The final, formatted version of the article will be published soon.

    We conducted a large-scale epidemiological analysis to investigate the associations between systemic inflammation markers and heart failure (HF). Our aim is to identify potential biomarkers for early detection of HF. Methods: A cross-sectional study was conducted using data from the National Health and Nutrition Examination Survey. We investigated the associations between five systemic inflammation markers (neutrophil to lymphocyte ratio [NLR], platelet to lymphocyte ratio [PLR], systemic immune inflammation index [SII], system inflammation response index [SIRI], and aggregate index of systemic inflammation [AISI]) and the risk of HF. Results: The prevalence rates of HF exhibited a gradual increase across increasing logNLR, logPLR, logSII, logSIRI, and logAISI tertiles. Compared to those in the highest tertiles of logNLR, logSII, logSIRI, and logAISI had a 1.579-fold, 1.341-fold, 1.956-fold, and 1.499-fold increased risk of HF compared to those in the lowest tertile respectively. Conversely, there was no significant correlation between logPLR and HF risk among subjects in the highest tertile. The restricted cubic splines (RCS) analysis revealed a non-linear relationship between the elevation of systemic inflammation markers and HF prevalence. Specifically, a per standard deviation increase in any of these variables is associated with a respective 45%, 29%, 28%, 44%and 29% increase in HF prevalence.The receiver operating characteristic (ROC) analysis demonstrated favorable sensitivity and specificity of these systemic inflammation markers in detecting the presence of HF.Conclusion: Our cross-sectional study demonstrates significant positive correlations between the NLR,PLR,SII, SIRI, and AISI with the incidence of HF.

    Keywords: systemic inflammation markers, Neutrophil to lymphocyte ratio, Platelet to lymphocyte ratio, systemic immune inflammation index, system inflammation response index, aggregate index of systemic inflammation, Heart Failure

    Received: 30 Jun 2024; Accepted: 26 Sep 2024.

    Copyright: © 2024 Huang, Shen, Yu, Jin, Hong, Luo, Chen and Rong. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Lei Huang, Ningbo Hangzhou Bay Hospital, Ningbo, China
    Jiacheng Rong, Ningbo Hangzhou Bay Hospital, Ningbo, China

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