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ORIGINAL RESEARCH article

Front. Cardiovasc. Med.
Sec. Cardiovascular Surgery
Volume 11 - 2024 | doi: 10.3389/fcvm.2024.1454371
This article is part of the Research Topic Insights in Heart Surgery: 2023 View all 6 articles

Predictive Value of NT-pro BNP on Outcomes of Children with ventricular septal defect Surgery

Provisionally accepted
Weidan Chen Weidan Chen 1Yajie Tang Yajie Tang 2Ye Lu Ye Lu 1*Ma Li Ma Li 1*Xinxin Chen Xinxin Chen 1*Techang Liu Techang Liu 1*
  • 1 Guangzhou Women and Children’s Medical Center, Guangzhou Medical University, Guangzhou, China
  • 2 Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, Beijing Municipality, China

The final, formatted version of the article will be published soon.

    Background: NoneLimited study has shown whether NT-pro BNPNT-proBNP is related to the prognosis of children with ventricular septal defect (VSD) surgery. The study was conducted to determine the predictive value of NT-pro BNPNT-proBNP on outcomes of children with VSD surgery. Methods: A total of 798 children with VSD surgery were enrolled, with NT-pro BNPNT-proBNP measured at preoperatively and 24-hour postoperatively. The short-and mid-term clinical outcomes were recorded. Propensity scores (PS) was performed to acquire pre-op and post-op NT pro-BNPpost NT-proBNP 24-hour PS-matched cohorts for comparisons between groups.Results: In the pre-op NT pro-BNPpre NT-proBNP PS-matched cohort, the higher NT pro-BNP group had longer hospitalization time and lower post-op 1-month EF value compared with low NT pro-BNP group (all P<0.05), and there wasn't significant difference of mechanical ventilation time, cardiopulmonary bypass (CPB) time, intensive care unit (CCU) stay, and ejection fraction (EF) values of 3 month to 12 months after surgery (all P>0.05). In the post-op NT pro-BNPpost NT-proBNP PS-matched cohort, there wasn't significant difference of mechanical ventilation time, CPB time, CCU stay, hospitalization time, and EF values of 1 month to 12 months after surgery between two groups (all P>0.05).Conclusions: VSD children with higher pre-op NT pro-BNPpre NT-proBNP level had longer hospital stays and worse cardiac function at 1 month after surgery than those with lower level.Pre-op NT pro-BNPPre NT-proBNP level had no effect on mechanical ventilation time, CPB

    Keywords: Ventricular septal defect, Children, NT-pro BNPNT-proBNP, Predictive Value, clinical outcomes

    Received: 25 Jun 2024; Accepted: 20 Dec 2024.

    Copyright: © 2024 Chen, Tang, Lu, Li, Chen and Liu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Ye Lu, Guangzhou Women and Children’s Medical Center, Guangzhou Medical University, Guangzhou, China
    Ma Li, Guangzhou Women and Children’s Medical Center, Guangzhou Medical University, Guangzhou, China
    Xinxin Chen, Guangzhou Women and Children’s Medical Center, Guangzhou Medical University, Guangzhou, China
    Techang Liu, Guangzhou Women and Children’s Medical Center, Guangzhou Medical University, Guangzhou, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.