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ORIGINAL RESEARCH article

Front. Cardiovasc. Med.
Sec. Hypertension
Volume 11 - 2024 | doi: 10.3389/fcvm.2024.1453563

Association between 'Life's Essential 8' cardiovascular health and apparent treatmentresistant hypertension among US adults from the NHANES,2005 to 2018

Provisionally accepted
zhongjiao xu zhongjiao xu *ruming shen ruming shen *wuming hu wuming hu *Jiayi Shen Jiayi Shen xiaoyan wu xiaoyan wu lingchun lv lingchun lv *
  • Fifth Affiliated Hospital of Wenzhou Medical University, Lishui, China

The final, formatted version of the article will be published soon.

    The association between healthy lifestyle and American Heart Association (AHA) Life's Essential 8 (LE8) score and apparent treatment-resistant hypertension(aTRH)remains uncertain. We aimed to explore the association between healthy lifestyle and higher LE8 score and apparent treatment-resistant hypertension in the general population.Methods: Using NHANES data from 2005-2018, we included and analyzed information on 7474 participants eligible for this study. The association between LE8 and aTRH was explored using logistic regression models, and the association between LE8 and antihypertension drugs uncontrolled hypertension was further explored using logistic regression models.Results: Participants with higher LE8 scores tended to be non-Hispanic white and married or living with a partner; have low income and higher education; and be without Chronic kidney disease (CKD)(all p values <0.001). Compared to subjects with low CVH, participants with moderate and high CVH exhibited lower risks of 47% and 76%, respectively. After adjusting for covariates, there was no evidence of a nonlinear association between LE8 and aTRH (p for nonlinearity = 0.456).Physical activity (PA), body mass index (BMI), and blood glucose were associated with aTRH (all p values < 0.05), while diet, nicotine exposure, sleep, and blood lipids were not significantly associated with aTRH. Compared to the low LE8 group, the ORs for the high LE8 group were 0.46 (95% CI, 0.28 to 0.76) and 0.07 (95% CI, 0.02 to 0.20) for uncontrolled hypertension with 1-2 and 3-4 antihypertensive drugs, respectively. In the sensitivity analysis, subgroup analyses were performed on all covariates, and the results remained stable.In our study, we found a significant association between higher LE8 scores and a lower risk of aTRH. Our findings suggest that implementing various healthy lifestyle practices and managing known cardiovascular risk factors could be a feasible comprehensive preventive approach to aTRH.

    Keywords: Cardiovascular health score, Healthy lifestyle, Life's Essential 8, Hypertension, AHA,American Heart Association, LE8,Life's Essential 8, LS7,Life's Simple 7, NHANES,National Health and Nutrition Survey

    Received: 27 Jun 2024; Accepted: 02 Dec 2024.

    Copyright: © 2024 xu, shen, hu, Shen, wu and lv. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    zhongjiao xu, Fifth Affiliated Hospital of Wenzhou Medical University, Lishui, China
    ruming shen, Fifth Affiliated Hospital of Wenzhou Medical University, Lishui, China
    wuming hu, Fifth Affiliated Hospital of Wenzhou Medical University, Lishui, China
    lingchun lv, Fifth Affiliated Hospital of Wenzhou Medical University, Lishui, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.