AUTHOR=Gerdes Norbert , Klingenberg Roland 

TITLE=Mini-Review: Immunogenic epitopes in apolipoprotein B-100 for atheroprotective immunization

JOURNAL=Frontiers in Cardiovascular Medicine

VOLUME=11

YEAR=2024

URL=https://www.frontiersin.org/journals/cardiovascular-medicine/articles/10.3389/fcvm.2024.1448664

DOI=10.3389/fcvm.2024.1448664

ISSN=2297-055X

ABSTRACT=<p>Here, we provide a concise overview of recent developments in the identification of immunogenic epitopes in human apolipoprotein B-100 for immunization against atherosclerotic cardiovascular disease. Major steps forward toward a clinical application of vaccines include the design of humanized mouse models, tetramer-based identification of antigen-specific T cells, and novel analysis tools, such as single-cell RNA sequencing and cytometry by time of flight, to assess temporal and spatial changes in immune cells in atherosclerotic cardiovascular disease.</p>