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MINI REVIEW article

Front. Cardiovasc. Med.
Sec. Lipids in Cardiovascular Disease
Volume 11 - 2024 | doi: 10.3389/fcvm.2024.1448664
This article is part of the Research Topic Evidence of Atherogenic Lipoproteins: what we gain from in vitro and in vivo research View all 3 articles

Mini-Review Immunogenic Epitopes in Apolipoprotein B-100 for Atheroprotective Immunization

Provisionally accepted
Norbert Gerdes Norbert Gerdes 1Roland Klingenberg Roland Klingenberg 2*
  • 1 Division of Cardiology, Pulmonology, and Vascular Medicine University Hospital and Medical Faculty Heinrich-Heine-University Düsseldorf, Düsseldorf, Germany
  • 2 Other, Bad Nauheim, Germany

The final, formatted version of the article will be published soon.

    Here we provide a concise overview of recent developments in the identification of immunogenic epitopes in human apolipoprotein B-100 for immunization against atherosclerotic cardiovascular disease. Major steps forward towards a clinical application of vaccines include the design of humanized mouse models, tetramerbased identification of antigen-specific T cells, and novel analysis tools, such as single-cell RNA sequencing and cytometry by time of flight, to assess temporal and spatial changes in immune cells in atherosclerotic cardiovascular disease.

    Keywords: Atherosclerosis, Lipoproteins, Immunity, Immunization, Inflammation

    Received: 13 Jun 2024; Accepted: 29 Jul 2024.

    Copyright: © 2024 Gerdes and Klingenberg. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Roland Klingenberg, Other, Bad Nauheim, Germany

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.