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ORIGINAL RESEARCH article

Front. Cardiovasc. Med.
Sec. Coronary Artery Disease
Volume 11 - 2024 | doi: 10.3389/fcvm.2024.1447829
This article is part of the Research Topic Advances and Dilemmas in Contemporary Management of Chronic Coronary Syndrome: Balancing Coronary Revascularization and Conservative Therapy View all 3 articles

The impact of successful chronic total occlusion percutaneous coronary intervention on clinical outcomes: a tertiary single-center analysis

Provisionally accepted
Maximilian Will Maximilian Will 1*Konstantin Schwarz Konstantin Schwarz 1Simone Aufhauser Simone Aufhauser 1Gregor Leibundgut Gregor Leibundgut 2Elisabeth Schmidt Elisabeth Schmidt 1David Mayer David Mayer 1Paul Vock Paul Vock 1Josip A. Borovac Josip A. Borovac 3Chun Shing Kwok Chun Shing Kwok 4Gudrun Lamm Gudrun Lamm 1Julia Mascherbauer Julia Mascherbauer 1Thomas Weiss Thomas Weiss 5
  • 1 St. Pölten University Hospital, Karl Landsteiner University of Health Sciences, Sankt Pölten, Austria
  • 2 Department of Cardiology, University Hospital of Basel, Basel, Switzerland
  • 3 University Hospital Split, Split, Split, Croatia
  • 4 University of Birmingham, Birmingham, England, United Kingdom
  • 5 Sigmund Freud University Vienna, Vienna, Vienna, Austria

The final, formatted version of the article will be published soon.

    The benefit of chronic total occlusion (CTO)-percutaneous coronary intervention (PCI) is controversial because of a lack of high-quality evidence. We aim to evaluate the impact of CTO-PCI on symptoms, quality of life and mortality.We conducted a retrospective single center study of patients with CTO-PCI in a tertiary center in Austria. The study outcomes were Canadian Cardiovascular Society (CCS) angina score, quality of life measured by Seattle Angina Questionnaire (SAQ), and death at median follow up for patients with successful versus failed CTO-PCI.A total of 300 patients underwent CTO-PCI for coronary artery disease, of which 252 (84%) were technically successful with median follow up of 3.4 years. There were no significant differences in in-hospital or all-cause mortality, major adverse cardiovascular event, or stentrelated complications between the groups of failed and successful CTO-PCI. Among patients with successful CTO-PCI there was a significant improvement in CCS score, which was not found for the group with failed CTO-PCI. Successful reopening was associated with significant benefits of the SAQ domains of angina with stressful activity (3.7±0.9 vs. 3.1±0.5, p=0.004, use of nitrates (4.7±0.5 vs. 3.0±1.0) p=0.005) and satisfaction from angina relief (4.4±1.1 vs.3.6±1.4 p<0.001).While there was no significant difference in mortality, successful CTO-PCI was associated with greater reduction in angina and the use of nitrates compared to unsuccessful CTO-PCI.

    Keywords: Coronary artery disease (CAD, chronic total occlusion (CTO, , percutaneous coronary intervention (PCI), Quality of Life, Symptoms, Mortality

    Received: 12 Jun 2024; Accepted: 10 Sep 2024.

    Copyright: © 2024 Will, Schwarz, Aufhauser, Leibundgut, Schmidt, Mayer, Vock, Borovac, Kwok, Lamm, Mascherbauer and Weiss. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Maximilian Will, St. Pölten University Hospital, Karl Landsteiner University of Health Sciences, Sankt Pölten, Austria

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