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ORIGINAL RESEARCH article

Front. Cardiovasc. Med.
Sec. Cardiovascular Epidemiology and Prevention
Volume 11 - 2024 | doi: 10.3389/fcvm.2024.1443906

Exploring the causality of appendectomy and ischaemic heart disease: a Mendelian randomization study and Meta-analysis

Provisionally accepted
Shuai Wang Shuai Wang Tao Zhang Tao Zhang Yuanlin Sun Yuanlin Sun Yiwei Yao Yiwei Yao Dongliang Yang Dongliang Yang Xueyuan Cao Xueyuan Cao *
  • Department of Gastric and Colorectal Surgery, General Surgery Center, the first hospital of jilin university, Changchun, China

The final, formatted version of the article will be published soon.

    The risk of ischaemic heart disease (IHD) is increased in appendectomy patients, but it is not clear whether there is a causal relationship. We aimed to systematically estimate the causal relationship between appendectomy and IHD and its subtypes, acute myocardial infarction (AMI) and angina pectoris (AP), using Mendelian randomization (MR) study methods and meta-analysis.As the discovery cohort analysis, we extracted independent genetic variants strongly associated with appendectomy from the FinnGen study (28,601 cases) as instrumental variables (IVs). Genome-wide association study (GWAS) from UK Biobank were selected for outcome data. A first two-sample MR analysis was then conducted. As the replication cohort, IVs associated with appendectomy were extracted in the UK Biobank (50,105 cases). GWAS from the FinnGen study were selected for outcome data. A second MR analysis was then performed. Finally, meta-analyses were applied to assess the combined causal effects of the MR results.In the discovery cohort, there was a significant positive causal relationship between appendectomy and IHD and its subtypes AMI and AP. The replication cohort only found a positive causal relationship between appendectomy and AMI. Meta-analysis showed a positive causal relationship between

    Keywords: Mendelian randomization1, appendectomy2, ischaemic heart disease3, myocardial infarction4, angina pectoris5

    Received: 04 Jun 2024; Accepted: 26 Jul 2024.

    Copyright: © 2024 Wang, Zhang, Sun, Yao, Yang and Cao. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Xueyuan Cao, Department of Gastric and Colorectal Surgery, General Surgery Center, the first hospital of jilin university, Changchun, China

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