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ORIGINAL RESEARCH article

Front. Cardiovasc. Med.
Sec. Coronary Artery Disease
Volume 11 - 2024 | doi: 10.3389/fcvm.2024.1440138

SALIVARY CARDIAC TROPONIN DOES NOT CORRELATE WITH SERUM LEVELS

Provisionally accepted
Hoa Tran Hoa Tran 1Vu Hoang Vu Vu Hoang Vu 1Dang Duy Quang Pham Dang Duy Quang Pham 2*Duc Minh Tran Duc Minh Tran 2Suong Thi Bang Nguyen Suong Thi Bang Nguyen 2Vien T. Truong Vien T. Truong 3Binh Quang Truong Binh Quang Truong 1
  • 1 Faculty of Medicine, University of Medicine and Pharmacy at Ho Chi Minh City, Ho Chi Minh City, Vietnam
  • 2 Other, Ho Chi Minh City, Vietnam
  • 3 Other, Cincinnati, Ohio, United States

The final, formatted version of the article will be published soon.

    Introduction: Several studies suggest a potential correlation between troponin levels detected in serum and saliva. However, prior investigations have not adequately addressed the critical aspect of collecting samples upon admission, which is essential for timely troponin level determination. This study aimed to evaluate the relationship between troponin levels in serum and saliva among patients admitted for chest pain evaluation. Methods: This observational study was conducted at the Interventional Cardiology Department of the University Medical Center HCMC. Patients presenting with chest pain were enrolled, and unstimulated saliva samples were collected using the Navazesh method simultaneously with the initial blood collection. These samples were then analyzed for levels of salivary troponin I, serum troponin I, and serum high-sensitive troponin T. Results: Among the 48 patients included, 22 (46%) exhibited myocardial injury, while 12 (25%) were diagnosed with acute myocardial infarction. No significant difference was observed in salivary troponin I levels between the non-myocardial injury and myocardial injury groups (p = 0.425). Moreover, no correlation was found between salivary troponin I levels and either serum troponin T or serum troponin I levels (Pearson correlation p = 0.761, 0.500; Spearman correlation p = 0.857, 0.136, respectively). The ROC curve for salivary troponin I in predicting myocardial injury displayed an AUC of 0.566 (95% CI 0.402–0.731), indicating poor discriminatory power. Conclusions: In our investigation, salivary troponin I failed to demonstrate a meaningful correlation with serum troponins, thereby limiting its practical utility in diagnosing myocardial injury or myocardial infarction. Further research is warranted to explore its diagnostic reliability and clinical applicability.

    Keywords: salivary troponin, Serum troponin, Correlation, Myocardial injury, Chest discomfort

    Received: 29 May 2024; Accepted: 23 Dec 2024.

    Copyright: © 2024 Tran, Vu, Pham, Tran, Nguyen, Truong and Truong. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Dang Duy Quang Pham, Other, Ho Chi Minh City, Vietnam

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