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ORIGINAL RESEARCH article

Front. Cardiovasc. Med.
Sec. Coronary Artery Disease
Volume 11 - 2024 | doi: 10.3389/fcvm.2024.1439913

The relationship between system inflammation response index and coronary heart disease: a cross-sectional study (NHANES 2007-2016)

Provisionally accepted
Tian Yang Zhang Tian Yang Zhang 1Hailong Chen Hailong Chen 1Yanyu Shi Yanyu Shi 1Ying Jin Ying Jin 2Yuan Zhang Yuan Zhang 1Ying Chen Ying Chen 3*
  • 1 Changchun University of Chinese Medicine, Changchun, China
  • 2 Changchun NanGuan District Hospital, Changchun, China
  • 3 The Affiliated Hospital of Changchun University of Traditional Chinese Medicine, Changchun, Jilin Province, China

The final, formatted version of the article will be published soon.

    Background: Coronary heart disease (CHD) is one of the common chronic diseases in clinical practice, often accompanied by inflammatory reactions. In recent years, the system inflammation response index (SIRI) has aroused researchers' interest as a novel inflammatory biomarker. This study aims to explore the relationship between the SIRI and CHD through the National Health and Nutrition Examination Survey (NHANES) database.We conducted a cross-sectional study and analyzed participants aged 40 and above with complete data from the NHANES survey years 2007-2016. Logistic regression analysis was used in this study to explore the relationship between the risk of CHD and SIRI. Stratified subgroup analysis was conducted based on age, gender, race, education level, body mass index (BMI), smoking status, drinking, hypertension, diabetes and angina pectoris to evaluate the relationship between SIRI and CHD in different populations. Additionally, restricted cubic spline (RCS) analysis was employed to investigate whether there is a nonlinear association between SIRI and CHD.Results: A total of 6374 eligible participants were included, among whom 387 were diagnosed with CHD. The SIRI levels in the CHD group were significantly higher than those in the non-CHD group. After adjusting for potential confounders, an elevated SIRI level was associated with an increased risk of CHD, with an odds ratio of 1.12, 95% CI: (1.03,1.22), P=0.008. Subgroup analysis results indicated a significant interaction between SIRI and CHD among genders (P for interaction < 0.05), especially in females. In contrast, no significant interaction was observed among age, race, education level, BMI, smoking status, drinking, hypertension, diabetes and angina pectoris (P for interaction > 0.05). The RCS analysis showed a significant linear relationship between SIRI and CHD (P for non-linearity > 0.05), with an inflection point at 2.86.Our study indicates that an elevated system inflammation response index is associated with a higher risk of CHD. Particularly among women.

    Keywords: system inflammation response index, Inflammation, coronary heart disease, NHANES, Cross-sectional study

    Received: 28 May 2024; Accepted: 24 Jul 2024.

    Copyright: © 2024 Yang Zhang, Chen, Shi, Jin, Zhang and Chen. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Ying Chen, The Affiliated Hospital of Changchun University of Traditional Chinese Medicine, Changchun, 130021, Jilin Province, China

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