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ORIGINAL RESEARCH article

Front. Cardiovasc. Med.
Sec. Atherosclerosis and Vascular Medicine
Volume 11 - 2024 | doi: 10.3389/fcvm.2024.1439699

The Causal Relationship Between 233 Metabolites and Coronary Atherosclerosis: A Mendelian Randomization Study

Provisionally accepted
Hongwei Zhang Hongwei Zhang 1Xiaoyu Zheng Xiaoyu Zheng 2Zian Yan Zian Yan 3Lijun Guo Lijun Guo 1Yuan Zheng Yuan Zheng 1Xiaochang Ma Xiaochang Ma 1*Dawu Zhang Dawu Zhang 1*
  • 1 National Clinical Research Center for Chinese Medicine Cardiology, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, China
  • 2 Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, China
  • 3 Institute of Basic Medical Sciences, Xiyuan Hospital of China Academy of Chinese Medical Sciences, Beijing, China., National Clinical Research Center for Chinese Medicine Cardiology, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, China

The final, formatted version of the article will be published soon.

    Objective: To investigate the causal relationship between 233 newly reported metabolites and coronary atherosclerosis through Mendelian randomization analysis.: Five different methods were used to perform Mendelian randomization analysis on the 233 metabolites and coronary atherosclerosis, with inverse variance weighting as the primary result, supplemented by other methods. Results: The analysis identified that certain metabolites increase the susceptibility risk of coronary atherosclerosis, including: Total fatty acids ( OR= 1.40,95%CI 1.28~1.53，p <0.001) ，Saturated fatty acids(OR= 1.44,95%CI 1.30 1.60，p <0.001) ，Serum total triglyceride levels(OR= 1.33,95%CI 1.22 ~1.46，p <0.001 )， Conjugated linoleic acid ( OR= 1.16,95%CI 1.04 ~1.30 ， p= 0.007 ) .Conversely, certain metabolites were found to reduce the occurrence of coronary atherosclerosis, such as: Cholesteryl esters to total lipids ratio in medium 2 HDL (OR= 0.73,95%CI 0.67 ~0.78， p <0.001) ， Cholesteryl esters to total lipids ratio in large HDL(OR= 0.64,95%CI 0.58 ~0.71，p <0.001) ，Total cholesterol to total lipids ratio in medium HDL(OR=0.71,95%CI 0.65 ~0.77，p <0.001).There is a close relationship between metabolites and the occurrence of coronary atherosclerosis. This study conducted Mendelian randomization analysis on the causal relationship between 233 metabolites and coronary atherosclerosis, providing potential new insights for the treatment of this disease.

    Keywords: Coronary atherosclerosis, metabolite, Mendelian randomization, causality, Lipid Metabolism

    Received: 28 May 2024; Accepted: 26 Nov 2024.

    Copyright: © 2024 Zhang, Zheng, Yan, Guo, Zheng, Ma and Zhang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Xiaochang Ma, National Clinical Research Center for Chinese Medicine Cardiology, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, China
    Dawu Zhang, National Clinical Research Center for Chinese Medicine Cardiology, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, China

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