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REVIEW article
Front. Cardiovasc. Med.
Sec. General Cardiovascular Medicine
Volume 11 - 2024 |
doi: 10.3389/fcvm.2024.1439402
This article is part of the Research Topic The Right Heart: A Key Target for Cardiovascular Medicine View all 4 articles
Chronic thromboembolic pulmonary hypertension: the diagnostic assessment
Provisionally accepted- 1 ICOT Istituto Marco Pasquali, Latina, Italy
- 2 Department of Clinical Internal, Anesthesiological and Cardiovascular Sciences, Sapienza University of Rome, Rome, Sicily, Italy
- 3 IRCCS Neuromed, Pozzilli (IS), Italy, Pozzilli, Italy
- 4 Department of Medical-Surgical Sciences and Biotechnologies, Sapienza University of Rome, Latina, Italy, Latina, Italy
- 5 Hospital Santa Maria Goretti, Latina, Italy
- 6 Department of Cardiovascular and Respiratory Sciences, Sapienza University of Rome, Rome, Sicily, Italy
Chronic Thromboembolic Pulmonary Hypertension (CTEPH) presents a significant diagnostic challenge due to its complex and often nonspecific clinical manifestations. This review outlines a comprehensive approach to the diagnostic assessment of CTEPH, emphasizing the importance of a high index of suspicion in patients with unexplained dyspnea or persistent symptoms post-acute pulmonary embolism. We discuss the pivotal role of multimodal imaging, including echocardiography, ventilation/perfusion scans, CT pulmonary angiography, and magnetic resonance imaging, in the identification and confirmation of CTEPH. Furthermore, the review highlights the essential function of right heart catheterization in validating the hemodynamic parameters indicative of CTEPH, establishing its definitive diagnosis. Advances in diagnostic technologies and the integration of a multidisciplinary approach are critical for the timely and accurate diagnosis of CTEPH, facilitating early therapeutic intervention and improving patient outcomes. This manuscript aims to equip clinicians with the knowledge and tools necessary for the efficient diagnostic workflow of CTEPH, promoting awareness and understanding of this potentially treatable cause of pulmonary hypertension.
Keywords: pulmonary hypertension, Chronic thromboembolic pulmonary hypertension (CTEPH), rare disease, diagnosis, Narrative review
Received: 27 May 2024; Accepted: 28 Aug 2024.
Copyright: © 2024 Simeone, Maggio, Schirone, Rocco, Sarto, Spadafora, Bernardi, Ambrosio, Forte, Vecchio, Valenti, Sciarretta and Vizza. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Beatrice Simeone, ICOT Istituto Marco Pasquali, Latina, Italy
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