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SYSTEMATIC REVIEW article

Front. Cardiovasc. Med.
Sec. Cardiovascular Epidemiology and Prevention
Volume 11 - 2024 | doi: 10.3389/fcvm.2024.1438817
This article is part of the Research Topic Body Composition Assessment and Future Disease Risk View all 7 articles

Association between waist-to-hip ratio and risk of myocardial infarction: a systematic evaluation and meta-analysis

Provisionally accepted
Xiao juan Zhang Xiao juan Zhang Liu Yang Liu Yang Cong Xiao Cong Xiao Jia cong Li Jia cong Li Tao Hu Tao Hu Lin feng Li Lin feng Li *
  • Jiangxi Provincial People's Hospital, Nanchang, Jiangxi Province, China

The final, formatted version of the article will be published soon.

    Background: Myocardial infarction(MI) is one of the most serious health threats. Despite the increasing number of clinical methods used to predict the onset of MI, the prediction of MI is still unsatisfactory and necessitates new methods. Objective:To systematically review observational studies from the past two decades on the association between waist-to-hip ratio (WHR) and MI risk. Methods:Original literature on the correlation between WHR and MI was searched in PubMed, Embase, Web of Science, Cochrane Library, Science Direct, CNKI, and Wanfang up to January 31, 2024. Two researchers independently screened, extracted data, and assessed quality using the Newcastle-Ottawa Scale（NOS）and Revman5.3. Meta-analysis with Stata16.0 calculated the combined Odd ratio（OR）for WHR and MI risk. Heterogeneity was assessed with the I² statistic to select the appropriate effects model. Subgroup analysis, meta-regression, sensitivity analysis, and funnel plots tested for heterogeneity and publication bias. Results: A total of 22 observational studies were included, involving 709093participants. The meta-analysis showed that an elevated WHR was significantly associated with an increased risk of MI, with a pooled odds ratio (OR) of 1.98[95% Confidence interval(CI): 1.75-2.24]and high heterogeneity (I²=91.5%, P<0.0001). Subgroup analysis revealed a stronger association between WHR and MI in women (OR: 1.99, 95% CI: 1.43-2.77) compared to men (OR: 1.74, 95% CI: 1.36-2.22). Regional analysis indicated that the association between WHR and MI risk was highest in Asian populations (OR: 2.93 95% CI: 1.61-5.33), followed by American (OR: 1.73, 95% CI: 1.45-2.08) and European populations (OR: 2.19, 95% CI: 1.49-3.22). Sensitivity analysis demonstrated that the results remained stable after excluding one study. Conclusion: In the general adult population, a higher WHR is a potentially significant association for MI and has predictive value for MI. Keywords: Waist-to-hip ratio; Myocardial infarction; Central obesity; Meta-analysis; Incidence rate

    Keywords: waist-to-hip ratio, Myocardial Infarction, Central obesity, Meta-analysis, Incidence rate

    Received: 31 May 2024; Accepted: 11 Nov 2024.

    Copyright: © 2024 Zhang, Yang, Xiao, Li, Hu and Li. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Lin feng Li, Jiangxi Provincial People's Hospital, Nanchang, 330006, Jiangxi Province, China

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