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ORIGINAL RESEARCH article

Front. Cardiovasc. Med.
Sec. Coronary Artery Disease
Volume 11 - 2024 | doi: 10.3389/fcvm.2024.1437096

The synergistic effect of the atherogenic index of plasma and hyperuricemia on the prediction of coronary chronic total occlusion lesion: An observational cross-sectional study

Provisionally accepted
Hongya Han Hongya Han 1Xiaoli Liu Xiaoli Liu 1Qi Zhao Qi Zhao 2ZhiJian Wang ZhiJian Wang 1Yan Sun Yan Sun 1Xiaoteng Ma Xiaoteng Ma 1Mengchen Li Mengchen Li 1Hanying Ma Hanying Ma 3Yuyang Liu Yuyang Liu 1Dongmei Shi Dongmei Shi 1Yujing Cheng Yujing Cheng 1*Yujie Zhou Yujie Zhou 1*
  • 1 Beijing Institute of Heart Lung and Blood Vessel Disease, Beijing Key Laboratory of Precision Medicine of Coronary Atherosclerotic Disease, Clinical center for coronary heart disease, Capital Medical University，100029, Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing, China
  • 2 Beijing Friendship Hospital, Capital Medical University, Beijing, Beijing Municipality, China
  • 3 100029, Department of General Medicine, Beijing Anzhen Hopital, Capital Medical University, Beijing, China

The final, formatted version of the article will be published soon.

    The atherogenic index of plasma (AIP) and hyperuricemia (HUA) have been shown to be closely associated with morbidity and mortality of coronary artery disease (CAD). However, there still lacks studies targeting predictive value of AIP and HUA for chronic total occlusion (CTO) lesions.Methods: Totally 5,238 patients meeting eligibility criteria were recruited in this analysis. CTO was defined as the lesions without forward blood flow and with over three months of occlusion time. AIP was calculated as Log10 [triglycerides (mmol/L)/high-density lipoprotein cholesterol (mmol/L)]. HUA was defined based on a sex-specific criteria: serum uric acid 420 and 360 μmol/L for males and females, respectively.Results: CTO lesions were presented in 907 (17.3%) patients. Compared with patients showing lower AIP levels and non-HUA, the CTO lesion risks increased by 5.225 and 2.765 times in patients with higher AIP levels and HUA. Patients with AIP > 0.15 and HUA exhibited the greatest CTO incidence [Odds ratio 11.491; 95% confidence interval 9.019-14.641, P < 0.001]. In addition, AIP combined with HUA had significantly increased effects (a 38.5% increase in CTO risk) relative to the sum of respective effects.Patients having higher AIP levels and HUA exhibited the highest CTO incidence, in comparison with patients who have the increased single index. AIP combined with HUA displayed significant synergistic effect on the prediction of CTO lesion.

    Keywords: coronary artery disease1, chronic total occlusion2, atherogenic index of plasma3, hyperuricemia4, prediction5

    Received: 23 May 2024; Accepted: 08 Jul 2024.

    Copyright: © 2024 Han, Liu, Zhao, Wang, Sun, Ma, Li, Ma, Liu, Shi, Cheng and Zhou. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Yujing Cheng, Beijing Institute of Heart Lung and Blood Vessel Disease, Beijing Key Laboratory of Precision Medicine of Coronary Atherosclerotic Disease, Clinical center for coronary heart disease, Capital Medical University，100029, Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing, 100029, China
    Yujie Zhou, Beijing Institute of Heart Lung and Blood Vessel Disease, Beijing Key Laboratory of Precision Medicine of Coronary Atherosclerotic Disease, Clinical center for coronary heart disease, Capital Medical University，100029, Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing, 100029, China

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