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ORIGINAL RESEARCH article

Front. Cardiovasc. Med.
Sec. Cardiovascular Epidemiology and Prevention
Volume 11 - 2024 | doi: 10.3389/fcvm.2024.1434963
This article is part of the Research Topic Women in Cardiovascular Epidemiology and Prevention View all 4 articles

Bidirectional Two-Sample Mendelian Randomization study of Atrial fibrillation and Breast cancer

Provisionally accepted
Fan Ding Fan Ding 1,2Chen Chen Chen Chen 1*Yuling Wang Yuling Wang 1,2Tingting Zhu Tingting Zhu 1*Linke Jiao Linke Jiao 1,2*Zihuan Shen Zihuan Shen 1,2Zhiwei Zhang Zhiwei Zhang 1*Lv Lvlifei Lv Lvlifei 1Xiangning Cui Xiangning Cui 1*Lu Yingdong Lu Yingdong 1*
  • 1 Guang’anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, China
  • 2 Graduate School of Beijing University of Chinese Medicine, Beijing, China

The final, formatted version of the article will be published soon.

    Background: Observational studies have shown an association between Breast Cancer (BC) and Atrial Fibrillation (AF). However, due to confounding factors and reverse causality, the causal role between BC and AF remains unclear. In this study, bidirectional two-sample Mendelian randomization (MR) combined with meta-analysis was used to evaluate the causal association between BC and AF.Methods: Based on the Genome-Wide Association Studies (GWAS) summary data sets, the Inverse variance weighted (IVW) method was used as the main method, the weighted median method and MR-Egger method were used for Bidirectional Two-Sample Mendelian Randomization, and the Egger intercept test was used to detect horizontal pleiotropy. Heterogeneity was tested by Cochran's Q test, and sensitivity analysis was performed by "leave-one-out". GWAS data for AF and BC were obtained from three separate databases (FinnGen, UKBiobank, GWAScatalog) for European individuals. Finally, meta-analysis was performed on the MR Analysis results from different databases. Results: The pooled IVW results showed no evidence of an effect of BC on the risk of AF (IVW: OR= 0.9994; 95%CI= 0.9967-1.0022). There was also no evidence of an effect of AF on BC risk (IVW: OR= 0.9970; 95%CI= 0.9154-1.0859).Conclusion: The results of the Bidirectional Two-Sample Mendelian Randomization study show that there is no causal relationship between BC and AF.

    Keywords: Atrial Fibrillation 1, Breast cancer 2, Mendelian randomization 3, meta-analysis4, causal association 5

    Received: 19 May 2024; Accepted: 28 Oct 2024.

    Copyright: © 2024 Ding, Chen, Wang, Zhu, Jiao, Shen, Zhang, Lvlifei, Cui and Yingdong. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Chen Chen, Guang’anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, China
    Tingting Zhu, Guang’anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, China
    Linke Jiao, Guang’anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, China
    Zhiwei Zhang, Guang’anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, China
    Xiangning Cui, Guang’anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, China
    Lu Yingdong, Guang’anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.