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ORIGINAL RESEARCH article

Front. Cardiovasc. Med.
Sec. Clinical and Translational Cardiovascular Medicine
Volume 11 - 2024 | doi: 10.3389/fcvm.2024.1434600

The role of Inflammatory Proteins in regulating the impact of Lipid Specifications on Deep Venous Thrombosis: A Two Sample and Mediated Mendelian Randomization Study

Provisionally accepted
Jiahao Sun Jiahao Sun 1*Dong Fan Dong Fan 2
  • 1 Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, China
  • 2 Shandong University of Traditional Chinese Medicine, Jinan, Shandong Province, China

The final, formatted version of the article will be published soon.

    Objective: To investigate the potential mediating role of inflammatory proteins in the association between lipid species and Deep Venous Thrombosis (DVT). Methods: A comprehensive analysis was conducted using pooled data from genome-wide association studies (GWAS), incorporating double-sample and reverse Mendelian randomization (MR) techniques, to identify the specific inflammatory proteins that act as intermediaries among 91 screened proteins in relation to deep vein thrombosis (DVT). Furthermore, a two-step MR approach was employed to quantify the proportion of DVT risk attributed to lipid effects mediated by these inflammatory proteins. Results: The MR Analysis revealed that the two inflammatory proteins, as predicted by genetics, served as mediating factors in the impact of five lipids on DVT. No reverse effect of DVT was observed on 179 lipid species and 91 inflammatory proteins. In the case of TAG(58:7) and its influence on DVT, CCL20 played an intermediary role with an estimated proportion of 12.51% (ranging from 12% to 13%). SIRT2 exhibited a masking effect on DVT for PC(17:0/20:4) and PC(18:0/20:4), while CCL20 masked the impact of DVT on PC(14:0/18:2), PC(15:0/18:2), and PC(18:0/20:5). Conclusions: In our study, we identified CCL20 as a crucial mediator in the association between TAG(58:7) and DVT, with a mediating proportion of 12.51% (12%-13%). Further investigations are warranted to explore other potential risk factors acting as mediators.

    Keywords: Lipid species, Inflammatory proteins, deep vein thrombosis, Mendelian randomization, Mediation role

    Received: 21 May 2024; Accepted: 01 Aug 2024.

    Copyright: © 2024 Sun and Fan. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Jiahao Sun, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.