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SYSTEMATIC REVIEW article

Front. Cardiovasc. Med.
Sec. Cardiovascular Epidemiology and Prevention
Volume 11 - 2024 | doi: 10.3389/fcvm.2024.1434265

Magnitude and Predictors of Poor Heart Failure Treatment Outcomes in Ethiopia: A Systematic Review and Meta-Analysis

Provisionally accepted
Firomsa Bekele Firomsa Bekele 1*Lalise Tafese Lalise Tafese 2Ginenus Fekadu Ginenus Fekadu 1Geleta Nenko Dube Geleta Nenko Dube 2Dinka Dugassa Dinka Dugassa 1Dagim Samuel Dagim Samuel 1
  • 1 College of Medical and Health Sciences, Wollega University, Nekemte, Oromia Region, Ethiopia
  • 2 Department of Health Informatics, College of Health Sciences, Mattu University, Mattu, Ethiopia

The final, formatted version of the article will be published soon.

    Background: Heart failure (HF) is a leading cause of morbidity and mortality worldwide. Various factors can exacerbate the disease progression in HF patients and negatively impact treatment outcomes. This study aims to evaluate the pooled prevalence and contributing factors associated with poor heart failure treatment outcomes in Ethiopia.A systematic review and meta-analysis were conducted using five databases: Google Scholar, ScienceDirect, HINARI, PubMed, and Scopus. Twelve studies met the eligibility criteria for inclusion in this analysis. The review followed the PRISMA 2020 guidelines. Data extraction was performed using a Microsoft Excel spreadsheet, and statistical analysis was conducted with STATA 14. The Joanna Briggs Institute Meta-analysis of Statistics Assessment and Review Instrument (JBI-MAStARI) was utilized for quality assessment. Heterogeneity among studies was evaluated using the I² statistic and the Cochrane Q test. Publication bias was assessed through Begg's test, Egger's weighted regression, and funnel plots.The pooled prevalence of poor HF treatment outcomes was found to be 16.67% (95% CI: 10.67-22.67). No significant heterogeneity was observed across the included studies (I² = 0.0%, p = 0.962). Significant predictors of poor treatment outcome were smoking cigarettes (AOR = 10.74; 95% CI: 3.24-35.63) and medication-related problems (AOR = 3.99; 95% CI: 1.90-8.37).The prevalence of poor HF treatment outcomes in Ethiopia was found to be high.Smoking cigarettes and medication-related problems are significant predictors of these adverse outcomes. Comprehensive health education and improved clinical pharmacy services are essential to address these issues

    Keywords: treatment outcome, Associated factors, Ethiopia, Heart failure\, magnitude

    Received: 06 Jun 2024; Accepted: 02 Dec 2024.

    Copyright: © 2024 Bekele, Tafese, Fekadu, Dube, Dugassa and Samuel. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Firomsa Bekele, College of Medical and Health Sciences, Wollega University, Nekemte, Oromia Region, Ethiopia

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.