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REVIEW article

Front. Cardiovasc. Med.
Sec. Cardiovascular Epidemiology and Prevention
Volume 11 - 2024 | doi: 10.3389/fcvm.2024.1434149
This article is part of the Research Topic Aging in Women: Estrogen, Oxidative Stress and Heart-Brain Axis View all articles

Risk Factors for Coronary Atherosclerotic Heart Disease in Postmenopausal Women: A Metaanalysis

Provisionally accepted
  • 1 College of Pharmaceutical Engineering & Life Science, Changzhou University, Changzhou, China
  • 2 Affliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, Liaoning Province, China
  • 3 Nanjing University of Chinese Medicine, Nanjing, Jiangsu Province, China

The final, formatted version of the article will be published soon.

    Background: Coronary atherosclerotic heart disease (coronary heart disease; CHD) is the leading ca use of death in women worldwide, and the number of patients and deaths is increasing each year. Ap proximately 3.8 million women die from CHD every year globally. After menopause, estrogen levels decrease, and the risk of cardiovascular disease increases substantially; however, research on risk fac tors for CHD in postmenopausal women has been inconclusive.To systematically evaluate the risk factors for CHD in postmenopausal women.The PubMed, Embase, Web of Science, CINAHL, CBM, CNKI, and VIP databases were s earched up to February 9, 2024, for studies on risk factors for CHD in postmenopausal women. Two researchers independently screened the literature, extracted data, and evaluated the quality of the incl uded literature. STATA17.0 software was used for meta-analysis.Results: Nine studies involving 294103 patients were included. The results of the meta-analysis sho wed that history of six or more pregnancies (hazard ratio = 1.538, 95% confidence interval: 1.241%-1.906%) was significantly associated with risk of CHD (P < 0.05).Multiple pregnancies are associated with CHD incidence and related mortality in postm enopausal women. In the future, more and higher quality studies are needed to further verify this con clusion.

    Keywords: postmenopausal women, Coronary atherosclerotic heart disease, Risk factors, meta-a nalysis, CHD Prevention

    Received: 17 May 2024; Accepted: 17 Dec 2024.

    Copyright: © 2024 Miao, Zhang, Wu, Wang and Wang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Xin Miao, College of Pharmaceutical Engineering & Life Science, Changzhou University, Changzhou, China
    Linlin Zhang, College of Pharmaceutical Engineering & Life Science, Changzhou University, Changzhou, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.