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REVIEW article
Front. Cardiovasc. Med.
Sec. Atherosclerosis and Vascular Medicine
Volume 11 - 2024 |
doi: 10.3389/fcvm.2024.1432468
Exercise mediates myocardial infarction via non-coding RNAs
Provisionally accepted- 1 Lishui University, Lishui, China
- 2 Beijing Sport University, Beijing, Beijing Municipality, China
- 3 City University Malaysia, Kuala Lumpur, Malaysia
- 4 Tsinghua University, Beijing, Beijing, China
- 5 Maragheh University of Medical Sciences, Maragheh, Iran
Myocardial infarction (MI), a widespread cardiovascular issue, mainly occurs due to blood clot formation in the coronary arteries, which reduces blood flow to the heart muscle and leads to cell death. Incorporating exercise into a lifestyle can significantly benefit recovery and reduce the risk of future cardiac events for MI patients. Non-coding RNAs (ncRNAs) play various roles in the effects of exercise on myocardial infarction (MI). ncRNAs regulate gene expression, influence cardiac remodeling, angiogenesis, inflammation, oxidative stress, apoptosis, cardioprotection, and cardiac electrophysiology. The expression of specific ncRNAs is altered by exercise, leading to beneficial changes in heart structure, function, and recovery after MI. These ncRNAs modulate molecular pathways that contribute to improved cardiac health, including reducing inflammation, enhancing angiogenesis, promoting cell survival, and mitigating oxidative stress. Furthermore, they are involved in regulating changes in cardiac remodeling, such as hypertrophy and fibrosis, and can influence the electrical properties of the heart, thereby decreasing the risk of arrhythmias.Knowledge on MI has entered a new phase, with investigations of ncRNAs in physical exercise yielding invaluable insights into the impact of this therapeutic modality. This review compiled research on ncRNAs in MI, with an emphasis on their applicability to physical activity.
Keywords: Exercise, Myocardial Infarction, non-coding RNAs, Cardioprotection, Apoptosis
Received: 14 May 2024; Accepted: 29 Sep 2024.
Copyright: © 2024 Han, Zhai, Li, Ma and Hallajzadeh. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Jamal Hallajzadeh, Maragheh University of Medical Sciences, Maragheh, Iran
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