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ORIGINAL RESEARCH article

Front. Cardiovasc. Med.
Sec. Heart Failure and Transplantation
Volume 11 - 2024 | doi: 10.3389/fcvm.2024.1430903

The predictive role of the TAPSE/sPAP ratio for cardiovascular events and mortality in systemic sclerosis with pulmonary hypertension

Provisionally accepted
Marco de Pinto Marco de Pinto 1*Francesca Coppi Francesca Coppi 2,3Clodoveo Ferri Clodoveo Ferri 1Gianluca Pagnoni Gianluca Pagnoni 2Vernizia Morgante Vernizia Morgante 2Pierluca Macripò Pierluca Macripò 1Matteo Boschini Matteo Boschini 4Anna F. Guerra Anna F. Guerra 5Francesca Tampieri Francesca Tampieri 2Ottavio Secchi Ottavio Secchi 1Martina Orlandi Martina Orlandi 1Gabriele Amati Gabriele Amati 1Federica Lumetti Federica Lumetti 1Gilda Sandri Gilda Sandri 1Rosario Rossi Rosario Rossi 2,6Giuseppe Boriani Giuseppe Boriani 2,6Anna V. Mattioli Anna V. Mattioli 7Clodoveo Ferri Clodoveo Ferri 1,3Dilia Giuggioli Dilia Giuggioli 1,3
  • 1 Scleroderma Unit, Rheumatology Unit, University Hospital of Modena and Reggio Emilia, Modena, Lombardy, Italy
  • 2 Cardiology Unit, Azienda Ospedaliero-Universitaria Policlinico di Modena, Modena, Italy
  • 3 Department of Medical and Surgical, Maternal-Infantile and Adult Sciences, University of Modena and Reggio Emilia, Modena, Lombardy, Italy
  • 4 Department of Engineering, University of Modena and Reggio Emilia, Modena, Emilia-Romagna, Italy
  • 5 Internal Medicine and Centre for Hemochromatosis, University Hospital of Modena, University of Modena and Reggio Emilia, Modena, Italy
  • 6 Cardiology Division, Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Policlinico di Modena, Modena, Italy
  • 7 Settore scienze tecniche e mediche applicate presso Alma Mater Studiorum, Università di Bologna, Bologna, Italy

The final, formatted version of the article will be published soon.

    A retrospective single-center study in which all patients having SSc -complicated by PH -referring to the Scleroderma-Unit of the AOU Policlinico of Modena, from October 2013 to October 2023 were evaluated.All SSc patients underwent recurrent clinical examination, routine blood chemistry analysis, functional, instrumental evaluation.61 SSc patients (F/M 52/9) were enrolled.During the follow-up, 60.1% of patients experienced at least one cardiovascular event and 62% died. The main causes of death were PH (39.4%) and other heart-related events (39.4%). The TAPSE/sPAP ratio was significantly lower in deceased patients compared to survivors (mm/mmHg 0.3 ± 0.12SD vs 0.48 ± 0.17SD, p<0.001).Compared to the SSc-PAH subgroup, the SSc-PH patients had lower survival rates (55.3 ±31.2 SD months vs 25 ± 19 SD, p=0,05).At the multivariate analysis, TAPSE/sPAP ratio <0.32 mm/mmHg, male gender, and the presence of significant ILD were identified as independent predictors of mortality and cardiovascular events.Our work confirmed the predictive role of the TAPSE/sPAP ratio for mortality and cardiovascular events in patients with SSc complicated by PH.

    Keywords: systemic sclerosis, pulmonary hypertension, pulmonary arterial hypertension, TAPSE, SPAP, Interstitial Lung Disease, Survival

    Received: 10 May 2024; Accepted: 23 Sep 2024.

    Copyright: © 2024 de Pinto, Coppi, Ferri, Pagnoni, Morgante, Macripò, Boschini, Guerra, Tampieri, Secchi, Orlandi, Amati, Lumetti, Sandri, Rossi, Boriani, Mattioli, Ferri and Giuggioli. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Marco de Pinto, Scleroderma Unit, Rheumatology Unit, University Hospital of Modena and Reggio Emilia, Modena, Lombardy, Italy

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