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ORIGINAL RESEARCH article

Front. Cardiovasc. Med.
Sec. Clinical and Translational Cardiovascular Medicine
Volume 11 - 2024 | doi: 10.3389/fcvm.2024.1430215

Prognostic potential of inflammatory markers in chronic kidney disease patients combined with acute myocardial infarction

Provisionally accepted
Peizhu Dang Peizhu Dang Bohan Li Bohan Li Yongxin Li Yongxin Li *
  • The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China

The final, formatted version of the article will be published soon.

    Background: Inflammation significantly impacts chronic kidney disease (CKD) and acute myocardial infarction (AMI). This study investigates the prognostic value of inflammatory markers in predicting outcomes for CKD patients with AMI.We enrolled patients diagnosed with CKD concomitant with AMI, choosing five inflammatory markers related to both diseases. Patients were categorized into elevated inflammatory markers and control groups based on inflammatory markers cut-off values for predicting in-hospital major adverse cardiac and cerebrovascular events (MACCE). Using univariate and multivariate logistic regression, we identified inflammation-related risk factors for MACCE. We adjusted covariates stepwise to explore the relationship between independent risk factors and adverse outcomes. We also evaluated the predictive value of these markers for MACCE by receiver operating characteristic (ROC) curves.In the multivariate logistic regression analysis, higher levels of neutrophil-tolymphocyte ratio (NLR), and platelet to lymphocyte ratio (PLR) significantly increased risk of MACCE (all P < 0.05). After adjusting above two indicators, NLR was independently associated with in-hospital MACCE in CKD patients with AMI (OR = 10.764, 95% CI: 1.887-61.406, P = 0.007). Furthermore, compared to other inflammatory markers, NLR had the highest predictive value for MACCE in patients with AMI and CKD [Area Under the Curve (AUC): 0.748, 95% Confidence Interval (CI): 0.634 -0.861, P < 0.001].In CKD patients combined with AMI, elevated levels of inflammation markers could increase the risk of MACCE. NLR may provide superior predictive value compared to other markers.Recent research highlights the critical role that inflammation plays in the development of various diseases, including myocardial infarction, stroke, renal failure, diabetes, and pulmonary diseases(7). The inflammatory response is not only a local process but can also have systemic

    Keywords: acute myocardial infarction1, chronic kidney disease2, inflammatory markers3, Neutrophil-to-Lymphocyte ratio4, Prognosis5

    Received: 06 Aug 2024; Accepted: 03 Dec 2024.

    Copyright: © 2024 Dang, Li and Li. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Yongxin Li, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.